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It has been recently demonstrated that sex steroids can negatively regulate beta-endorphin content as well as proopiomelanocortin (POMC) mRNA levels in the rat basal hypothalamus. In order to verify whether or not all the POMC neurons are equally affected by sex steroids, we arbitrarily divided the arcuate nucleus rostro-caudally into four equal portions and used an in situ hybridization technique to evaluate POMC gene expression in these different regions of the arcuate nucleus in the female rat. It was shown that ovariectomy induced an increase in mRNA levels in the most rostral region of the arcuate nucleus, an effect which was reversed by the concurrent administration of estradiol and dihydrotestosterone. On the other hand, estrogen administration to ovariectomized animals produced a marked depression of mRNA levels in all the regions of the arcuate nucleus with the exception of the most caudal one. These results suggest that sex steroids exert their action in subpopulations of POMC neurons.
Y Tong, and
H F Zhao, and
F Labrie, and
G Pelletier
April 1989,
Endocrinology,
Y Tong, and
H F Zhao, and
F Labrie, and
G Pelletier
August 1988,
Molecular endocrinology (Baltimore, Md.),
Y Tong, and
H F Zhao, and
F Labrie, and
G Pelletier
October 1992,
Journal of neuroendocrinology,
Y Tong, and
H F Zhao, and
F Labrie, and
G Pelletier
May 2000,
Endocrinology,
Y Tong, and
H F Zhao, and
F Labrie, and
G Pelletier
August 1990,
Molecular and cellular neurosciences,
Y Tong, and
H F Zhao, and
F Labrie, and
G Pelletier
March 1995,
Brain research,
Y Tong, and
H F Zhao, and
F Labrie, and
G Pelletier
December 1985,
Endocrinology,
Y Tong, and
H F Zhao, and
F Labrie, and
G Pelletier
November 1986,
Endocrinology,
Y Tong, and
H F Zhao, and
F Labrie, and
G Pelletier
January 1994,
Peptides,
Y Tong, and
H F Zhao, and
F Labrie, and
G Pelletier
March 1991,
Molecular endocrinology (Baltimore, Md.),
