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The use of 270 MHz Fourier Transform nuclear magnetic resonance (NMR) spectrometer, combined with signal processing techniques to improve resolution, enabled proton resonances from the individual aromatic residues of haemoglobin to be distinguished. In the presence of clinical concentrations of the general anaesthetic drugs halothane and methoxyflurane, specific changes in the NMR spectrum can be distinguished which probably reflect local changes of conformation. When higher concentrations of anaesthetic are used, extensive changes in the NMR spectrum occur which are consistent with non-specific binding of the anaesthetic to the hydrophobic parts of the haemoglobin molecule.
R W Barker, and
F F Brown, and
R Drake, and
M J Halsey, and
R E Richards
June 1972,
Nature: New biology,
R W Barker, and
F F Brown, and
R Drake, and
M J Halsey, and
R E Richards
March 1970,
Nature,
R W Barker, and
F F Brown, and
R Drake, and
M J Halsey, and
R E Richards
March 1976,
Molecular pharmacology,
R W Barker, and
F F Brown, and
R Drake, and
M J Halsey, and
R E Richards
January 1991,
Ciba Foundation symposium,
R W Barker, and
F F Brown, and
R Drake, and
M J Halsey, and
R E Richards
December 1969,
Chemistry and physics of lipids,
R W Barker, and
F F Brown, and
R Drake, and
M J Halsey, and
R E Richards
November 1968,
Canadian Anaesthetists' Society journal,
R W Barker, and
F F Brown, and
R Drake, and
M J Halsey, and
R E Richards
February 1994,
Biochemical Society transactions,
R W Barker, and
F F Brown, and
R Drake, and
M J Halsey, and
R E Richards
December 1981,
Biochemistry,
R W Barker, and
F F Brown, and
R Drake, and
M J Halsey, and
R E Richards
October 1971,
The Journal of pharmacy and pharmacology,
R W Barker, and
F F Brown, and
R Drake, and
M J Halsey, and
R E Richards
February 1983,
Biochemistry,
