Sub-150 nm mesoporous silica nanoparticles with tunable pore sizes and well-ordered mesostructure for protein encapsulation. 2013

Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. jinlougu@ecust.edu.cn

Despite their great potentials as biomacromolecues delivery vehicles, there are few, if any, reports on mesoporous silica nanoparticles (MSNs) simultaneously integrated with the merits of large pore size, small particle diameters and well-ordered mesostructure. Here, we designed a facile strategy for the synthesis of monodispersed MSNs using cationic surfactants (CSs) as templating agents, neutral amine of N,N-dimethylhexadecylamine (DMHA) as a pore size mediator and tri-block copolymer of F127 (EO106PO70EO106) as a particle growth inhibitor/dispersant. The obtained colloidal nanoparticles exhibited a highly ordered mesostructure and tunable pore diameter up to 4.6 nm (BJH) and monodispersed particle sizes less than 150 nm. A model protein of cytochrome c (CytC) was exemplified to be accommodated in the resultant MSNs and its loading amount was correlated with their pore size. The efficient cancer cellular uptake of the large-pore MSNs prefigured their potentials as intracellular delivery vehicles for membrane-impermeable proteins.

UI MeSH Term Description Entries
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D005456 Fluorescent Dyes Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. Flourescent Agent,Fluorescent Dye,Fluorescent Probe,Fluorescent Probes,Fluorochrome,Fluorochromes,Fluorogenic Substrates,Fluorescence Agents,Fluorescent Agents,Fluorogenic Substrate,Agents, Fluorescence,Agents, Fluorescent,Dyes, Fluorescent,Probes, Fluorescent,Substrates, Fluorogenic
D006367 HeLa Cells The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. Cell, HeLa,Cells, HeLa,HeLa Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012822 Silicon Dioxide Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid. Silica,Aerosil,Aerosil 380,Cristobalite,Quso G-32,Quso G32,Tridymite,380, Aerosil,Dioxide, Silicon,G32, Quso,Quso G 32
D014961 X-Ray Diffraction The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Xray Diffraction,Diffraction, X-Ray,Diffraction, Xray,Diffractions, X-Ray,Diffractions, Xray,X Ray Diffraction,X-Ray Diffractions,Xray Diffractions
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D046529 Microscopy, Electron, Transmission Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen. Electron Diffraction Microscopy,Electron Microscopy, Transmission,Microscopy, Electron Diffraction,Transmission Electron Microscopy,Diffraction Microscopy, Electron,Microscopy, Transmission Electron
D053758 Nanoparticles Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging. Nanocrystalline Materials,Nanocrystals,Material, Nanocrystalline,Materials, Nanocrystalline,Nanocrystal,Nanocrystalline Material,Nanoparticle
D053838 Scattering, Small Angle Scattering of a beam of electromagnetic or acoustic RADIATION, or particles, at small angles by particles or cavities whose dimensions are many times as large as the wavelength of the radiation or the de Broglie wavelength of the scattered particles. Also know as low angle scattering. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Small angle scattering (SAS) techniques, small angle neutron (SANS), X-ray (SAXS), and light (SALS, or just LS) scattering, are used to characterize objects on a nanoscale. Small Angle Scattering,Low Angle Scattering,Scattering, Low Angle,Angle Scattering, Low,Angle Scatterings, Low,Low Angle Scatterings,Scatterings, Low Angle

Related Publications

Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
July 2015, Nanoscale,
Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
August 2021, ACS applied materials & interfaces,
Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
October 2009, Nanoscale research letters,
Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
February 1999, Science (New York, N.Y.),
Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
July 2023, Nanomaterials (Basel, Switzerland),
Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
August 2014, Advanced materials (Deerfield Beach, Fla.),
Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
September 2020, ACS omega,
Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
September 2011, Journal of colloid and interface science,
Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
August 2014, Chemphyschem : a European journal of chemical physics and physical chemistry,
Jinlou Gu, and Kai Huang, and Xiangyang Zhu, and Yongsheng Li, and Jie Wei, and Wenru Zhao, and Changsheng Liu, and Jianlin Shi
August 2012, Journal of the American Chemical Society,
Copied contents to your clipboard!