-transparent.png){kind=logo}
In vivo 19F NMR measurements of trifluorinated neuroleptics in the rat brain were made using a 13 x 18 mm surface coil at 4.7 T. The signal of fluphenazine was obtained within 8-15 min from brains of living rats treated chronically with drug doses of 5-30 mg/kg. Following the intravenous injection of a single dose of trifluoperazine (30 mg/kg), brain levels could be monitored with a time resolution of 30 min. The data demonstrate the possibility of obtaining in vivo pharmacokinetics of fluorinated agents in the rat brain. 19F NMR is expected to become an important tool in neurochemical research.
Related Publications
K Albert, and
H Rembold, and
G Kruppa, and
E Bayer, and
M Bartels, and
G Schmalzing
January 1993,
NMR in biomedicine,
K Albert, and
H Rembold, and
G Kruppa, and
E Bayer, and
M Bartels, and
G Schmalzing
October 1991,
Biological psychiatry,
K Albert, and
H Rembold, and
G Kruppa, and
E Bayer, and
M Bartels, and
G Schmalzing
November 1990,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
K Albert, and
H Rembold, and
G Kruppa, and
E Bayer, and
M Bartels, and
G Schmalzing
September 1985,
The Journal of endocrinology,
K Albert, and
H Rembold, and
G Kruppa, and
E Bayer, and
M Bartels, and
G Schmalzing
April 1989,
Investigational new drugs,
K Albert, and
H Rembold, and
G Kruppa, and
E Bayer, and
M Bartels, and
G Schmalzing
October 1992,
The Journal of investigative dermatology,
K Albert, and
H Rembold, and
G Kruppa, and
E Bayer, and
M Bartels, and
G Schmalzing
November 1985,
Circulation,
K Albert, and
H Rembold, and
G Kruppa, and
E Bayer, and
M Bartels, and
G Schmalzing
December 1990,
Psychiatry research,
K Albert, and
H Rembold, and
G Kruppa, and
E Bayer, and
M Bartels, and
G Schmalzing
October 1991,
Cancer research,
K Albert, and
H Rembold, and
G Kruppa, and
E Bayer, and
M Bartels, and
G Schmalzing
January 1999,
Cancer research,
