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It has been proposed that multiple quantum filtered (MQF) 23Na NMR spectroscopy may distinguish between sodium in the intra- and extracellular spaces, in vivo, and without the requirement for toxic shift reagents. We have investigated the origin of such signals in perfused rat hearts, using shift reagents to discriminate between NMR signals from the two compartments. We find that the observed MQF signal arises predominantly from the extracellular space in the normal heart, and from the intracellular space in the ischaemic heart. However, the quenching effect of the shift reagent may hide some of the extracellular MQF signal, especially during ischaemia. Estimates of intracellular and extracellular relaxation times are obtained and possible mechanisms of the interaction discussed.
G S Payne, and
A M Seymour, and
P Styles, and
G K Radda
June 1999,
Magnetic resonance in medicine,
G S Payne, and
A M Seymour, and
P Styles, and
G K Radda
January 1993,
Magnetic resonance in medicine,
G S Payne, and
A M Seymour, and
P Styles, and
G K Radda
July 1994,
Biophysical journal,
G S Payne, and
A M Seymour, and
P Styles, and
G K Radda
July 1998,
Biophysical chemistry,
G S Payne, and
A M Seymour, and
P Styles, and
G K Radda
November 1997,
Magnetic resonance in medicine,
G S Payne, and
A M Seymour, and
P Styles, and
G K Radda
November 2007,
Journal of magnetic resonance (San Diego, Calif. : 1997),
G S Payne, and
A M Seymour, and
P Styles, and
G K Radda
July 1997,
Journal of magnetic resonance (San Diego, Calif. : 1997),
G S Payne, and
A M Seymour, and
P Styles, and
G K Radda
September 2015,
Journal of molecular and cellular cardiology,
G S Payne, and
A M Seymour, and
P Styles, and
G K Radda
February 2001,
Journal of the American Chemical Society,
G S Payne, and
A M Seymour, and
P Styles, and
G K Radda
June 1993,
Biochimica et biophysica acta,
