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Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series. 2013
Sreekanth Ramachandran, and
Manoranjan Panda, and
Kakoli Mukherjee, and
Nilanjana Roy Choudhury, and
Subramanyam J Tantry, and
Chaitanya Kumar Kedari, and
Vasanthi Ramachandran, and
Sreevalli Sharma, and
V K Ramya, and
Supreeth Guptha, and
Vasan K Sambandamurthy
Department of Medicinal Chemistry, AstraZeneca India Pvt Ltd, Avishkar, Bellary Road, Hebbal, Bangalore 560024, India. sreekanth.ramachandran@astrazeneca.com
Imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead were generated by whole cell screening of a focused library against Mycobacterium tuberculosis. Herein, we describe the synthesis and structure activity relationship evaluation of this class of inhibitors and the optimization of physicochemical properties. These are selective inhibitors of Mycobacterium tuberculosis with no activity on either gram positive or gram negative pathogens.
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