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Our efforts to overcome the fatal GVH disease following transplantation of incompatible bone marrow have been: 1) isolation of patient in sterile laminar flow room, 2) elimination of bacterial flora from GI tract, 3) repeated infusions of plasma containing blocking antibodies, 4) selection of HL-A identical but unrelated donor from general population, 5) use of stem-cell fraction of bone marrow and 6) gradual transplantation of marrow (less than 0.01 ml) carefully aspirated, free of immunocompetent T-cell contamination. A mild form of GVH disease, partial reconstitution of immune function and hematologic chimera were noted in 2 patients, who survived 67 days and 125 days after transplantation. More recently, an infant with severe combined immunodeficiency disease (SCID) has been reconstituted immunologically using marrow from HL-A mismatched, mixed leukocytes culture (MLC) non-reactive donor. The gradual transplantation method may be a useful means of transplanting incompatible marrow in infants with SCID.
B Y Park, and
W D Biggar, and
R A Good
January 1975,
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B Y Park, and
W D Biggar, and
R A Good
September 1971,
Lancet (London, England),
B Y Park, and
W D Biggar, and
R A Good
January 1974,
Bollettino dell'Istituto sieroterapico milanese,
B Y Park, and
W D Biggar, and
R A Good
January 1993,
Lancet (London, England),
B Y Park, and
W D Biggar, and
R A Good
September 2001,
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B Y Park, and
W D Biggar, and
R A Good
January 1978,
Pathologie-biologie,
B Y Park, and
W D Biggar, and
R A Good
December 1978,
Transplantation,
B Y Park, and
W D Biggar, and
R A Good
January 1978,
Pathologie-biologie,
B Y Park, and
W D Biggar, and
R A Good
June 1991,
The American review of respiratory disease,
B Y Park, and
W D Biggar, and
R A Good
May 2000,
Bone marrow transplantation,
