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The pharmacokinetics, clinical efficacy and side effects of carbamazepine (CBZ) in the steady-state condition were studied using a slow-release preparation (SR), Neurotol Slow, and a conventional preparation (C), Tegretol. Eighteen adult epileptic patients under CBZ therapy were evaluated in this single-blind, randomized cross-over study. The previous daily CBZ dose was kept unchanged and divided into 2 daily doses during two 2 week study periods. At the end of each period blood samples were drawn at frequent intervals for 12 h after the administration of the morning CBZ dose. Serum concentrations of unchanged CBZ and its main metabolite, carbamazepine-10,11-epoxide (CBZE), were determined by HPLC. Peak concentrations of CBZ and CBZE were significantly lower, and the time-lapse before CBZ reached its peak was significantly longer during SR treatment. The fluctuations in serum CBZ and CBZE were significantly lower during SR treatment. There was no significant difference in bioavailability between the 2 preparations. The number of epileptic seizures was 31 during SR and 57 during C treatment. Side effects were more common during C treatment. The occurrence of dizziness was significantly lower with SR treatment than with C treatment. We conclude that greater stability in serum CBZ and CBZE concentrations can be obtained by using an SR of CBZ, without reducing the bioavailability of the drug.
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H Lehto, and
E Hokkanen
March 1995,
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M Reunanen, and
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E Hokkanen
August 1990,
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M Reunanen, and
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P Järvensivu, and
H Lehto, and
E Hokkanen
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M Reunanen, and
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P Järvensivu, and
H Lehto, and
E Hokkanen
July 1990,
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M Reunanen, and
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P Järvensivu, and
H Lehto, and
E Hokkanen
December 1983,
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M Reunanen, and
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H Lehto, and
E Hokkanen
June 1991,
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M Reunanen, and
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M Anttila, and
P Järvensivu, and
H Lehto, and
E Hokkanen
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M Reunanen, and
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M Anttila, and
P Järvensivu, and
H Lehto, and
E Hokkanen
January 1992,
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M Reunanen, and
E Heinonen, and
M Anttila, and
P Järvensivu, and
H Lehto, and
E Hokkanen
February 1980,
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M Reunanen, and
E Heinonen, and
M Anttila, and
P Järvensivu, and
H Lehto, and
E Hokkanen
September 1989,
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