Biomaterial Database

An investigation of some factors affecting levels of erythrocyte inorganic pyrophosphatase activity. 1975

R A Fisher, and B M Turner, and H Dorkin, and H Harris

A reproducible method has been devised for assaying erythrocyte inorganic pyrophosphatase. The activity level in healthy individuals appears to be a constant characteristic. Population surveys have been carried out in 100 Europeans and 34 Indians. In each population an otherwise normal individual was found with activity approximately three standard deviations from the mean. Investigation of the family of one such individual indicated that this was an inherited characteristic. A few individuals with clinical abnormalities were examined and some were found to have activity levels above the normal range. High activity levels appeared to be associated with those diseases in which raised circulating reticulocyte levels are found. The rate of in vivo decay of erythrocyte inorganice pyrophosphatase has been measured in healthy individuals. The decay pattern appears to be of the constant logarithmic type. An estimate has been made of the activity in circulating reticulocytes, and the half life of the enzymes has been calculated.

UI	MeSH Term	Description	Entries
D007194	India	A country in southern Asia, bordering the Arabian Sea and the Bay of Bengal, between Burma and Pakistan. The capitol is New Delhi.	Republic of India
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008131	London	The capital of the United Kingdom. It is located in England.
D008297	Male		Males
D008722	Methods	A series of steps taken in order to conduct research.	Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010375	Pedigree	The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.	Family Tree,Genealogical Tree,Genealogic Tree,Genetic Identity,Identity, Genetic,Family Trees,Genealogic Trees,Genealogical Trees,Genetic Identities,Identities, Genetic,Tree, Family,Tree, Genealogic,Tree, Genealogical,Trees, Family,Trees, Genealogic,Trees, Genealogical
D010710	Phosphates	Inorganic salts of phosphoric acid.	Inorganic Phosphate,Phosphates, Inorganic,Inorganic Phosphates,Orthophosphate,Phosphate,Phosphate, Inorganic
D011755	Pyrophosphatases	A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, chiefly in nucleoside di- and triphosphates. They may liberate either a mono- or diphosphate. EC 3.6.1.-.	Pyrophosphatase
D002499	Centrifugation, Density Gradient	Separation of particles according to density by employing a gradient of varying densities. At equilibrium each particle settles in the gradient at a point equal to its density. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Centrifugations, Density Gradient,Density Gradient Centrifugation,Density Gradient Centrifugations,Gradient Centrifugation, Density,Gradient Centrifugations, Density