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Daily intraperitoneal injection of cadmium chloride (1 mg/kg) for 45 days significantly increased adrenal weights and augmented the levels of adrenal norepinephrine and epinephrine as well as the activity of adrenal tyrosine hydroxylase. Discontinuation of the heavy metal treatment for 28 days, in rats previously injected with cadmium for 45 days, restored the activity of tyrosine hydroxylase as well as the amount of norepinephrine and epinephrine. In contrast, adrenal weights were restored only partially following the withdrawal of cadmium treatment. Evidence indicates that the changes in adrenal catecholamine metabolism may be the result of stress induced by chronic exposure to this heavy metal. In addition, some of the untoward effects such as hyperglycemia and arterial hypertension seen during cadmium toxicity might be related to increased synthesis of epinephrine in adrenal glands.
R B Rastogi, and
R L Singhal
August 1990,
Ecotoxicology and environmental safety,
R B Rastogi, and
R L Singhal
January 1992,
Roczniki Panstwowego Zakladu Higieny,
R B Rastogi, and
R L Singhal
January 1982,
Endocrinologie,
R B Rastogi, and
R L Singhal
July 1982,
Toxicology letters,
R B Rastogi, and
R L Singhal
January 1962,
Proceedings of the Western Pharmacology Society,
R B Rastogi, and
R L Singhal
September 1976,
Toxicology and applied pharmacology,
R B Rastogi, and
R L Singhal
January 1996,
Bollettino della Societa italiana di biologia sperimentale,
R B Rastogi, and
R L Singhal
January 1973,
Acta physiologica latino americana,
R B Rastogi, and
R L Singhal
January 1975,
Naunyn-Schmiedeberg's archives of pharmacology,
R B Rastogi, and
R L Singhal
December 1973,
Biochemical pharmacology,
