-transparent.png){kind=logo}
The anti-inflammatory compound d-ibuprofen has been investigated for anti-inflammatory and cyclooxygenase inhibitory activity in ocular inflammation induced by paracentesis of eyes of living rabbits. d-Ibuprofen is the dextro-rotary isomer of ibuprofen, a potent non-steroidal anti-inflammatory agent. Eyes pretreated topically with d-ibuprofen 0.8% showed a significant inhibition of aqueous protein (73.0%) and prostaglandin E2 (96.4%) increase after paracentesis as compared to paracentesized untreated fellow eyes and control eyes. In aqueous humor no significant correlation between the increase in prostaglandin E2 and protein could be established after paracentesis. These results indicate that d-ibuprofen could be a useful ocular anti-inflammatory agent as cyclooxygenase inhibitor.
G W Tjebbes, and
J L van Delft, and
E R Barthen, and
N J van Haeringen
January 1991,
Journal of ocular pharmacology,
G W Tjebbes, and
J L van Delft, and
E R Barthen, and
N J van Haeringen
January 1990,
Journal of ocular pharmacology,
G W Tjebbes, and
J L van Delft, and
E R Barthen, and
N J van Haeringen
October 1981,
Experimental eye research,
G W Tjebbes, and
J L van Delft, and
E R Barthen, and
N J van Haeringen
January 1980,
Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology,
G W Tjebbes, and
J L van Delft, and
E R Barthen, and
N J van Haeringen
February 1975,
Experimental eye research,
G W Tjebbes, and
J L van Delft, and
E R Barthen, and
N J van Haeringen
July 1987,
Current eye research,
G W Tjebbes, and
J L van Delft, and
E R Barthen, and
N J van Haeringen
January 1989,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
G W Tjebbes, and
J L van Delft, and
E R Barthen, and
N J van Haeringen
March 1971,
Archives of ophthalmology (Chicago, Ill. : 1960),
G W Tjebbes, and
J L van Delft, and
E R Barthen, and
N J van Haeringen
May 1985,
Experimental eye research,
G W Tjebbes, and
J L van Delft, and
E R Barthen, and
N J van Haeringen
March 2006,
Vision research,
