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Seroreactivity to Plasmodium falciparum erythrocyte membrane protein 1 intracellular domain in malaria-exposed children and adults. 2013
Mark A Travassos, and
Amadou Niangaly, and
Jason A Bailey, and
Amed Ouattara, and
Drissa Coulibaly, and
Matthew B Laurens, and
Jozelyn Pablo, and
Algis Jasinskas, and
Rie Nakajima-Sasaki, and
Andrea A Berry, and
Shannon Takala-Harrison, and
Bourema Kouriba, and
J Alexandra Rowe, and
Kirsten E Lyke, and
Ogobara K Doumbo, and
Mahamadou A Thera, and
Philip L Felgner, and
Christopher V Plowe
Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore.
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens mediate parasite sequestration and host immune evasion. Reactivity to 21 PfEMP1 fragments on a protein microarray was measured in serum samples from Malian children aged 1-6 years and adults. Seroreactivity to PfEMP1 fragments was higher in adults than in children; intracellular conserved fragments were more widely recognized than were extracellular hypervariable fragments. Over a malaria season, children maintained this differential seroreactivity and recognized additional intracellular PfEMP1 fragments. This approach has the potential to identify conserved, seroreactive extracellular PfEMP1 domains critical for protective immunity to malaria.
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