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Both the systemic and local reactions caused by the immunization with the vaccine against diphtheria, tetanus and whooping cough were studied. Side-effects, 48 hours after the vaccination were determined in 730 children between the ages of two months and five years and 11 months. Over 13% of the children were free from side-effects. Eighty-seven percent of the children immunized showed the following side-effects in percentages of frequency: fever, 66.0%; malaise, 37.8%; loss of appetite, 25.0%; sleep disorders, 20.4%; vomiting, 7.9%; and continuous crying, 7.6%. With respect to local disturbances: pain, 41.6%; reddening, 28.0% and subcutaneous nodules, 20.1%. None of the children had convulsions, hypotonic episodes or immediate neurological damage. Two types of DTP vaccines, one from the Connaught (Canadian) Laboratory and another from the National Institute of Hygiene (Venezuelan) were used. No significant differences were found in the appearance of the side-effects between the both, except for localized pain (P less than 0.01) with the national vaccine. The results obtained in relation to age and the number of doses were: there was a significant increase of localized pain as ages increased (P less than 0.01). There were significantly greater number of localized pain and subcutaneous nodules with greater numbers of doses (P less than 0.01).
M E Regalado, and
B Nieves Rodríguez, and
M T Ghersy, and
M Amilachwari, and
J R Nieto, and
G Velásquez
March 1961,
Ugeskrift for laeger,
M E Regalado, and
B Nieves Rodríguez, and
M T Ghersy, and
M Amilachwari, and
J R Nieto, and
G Velásquez
December 1945,
The American journal of nursing,
M E Regalado, and
B Nieves Rodríguez, and
M T Ghersy, and
M Amilachwari, and
J R Nieto, and
G Velásquez
January 1948,
Physician's bulletin,
M E Regalado, and
B Nieves Rodríguez, and
M T Ghersy, and
M Amilachwari, and
J R Nieto, and
G Velásquez
January 1960,
Rivista dell'Istituto sieroterapico italiano,
M E Regalado, and
B Nieves Rodríguez, and
M T Ghersy, and
M Amilachwari, and
J R Nieto, and
G Velásquez
June 1966,
The New Zealand medical journal,
M E Regalado, and
B Nieves Rodríguez, and
M T Ghersy, and
M Amilachwari, and
J R Nieto, and
G Velásquez
January 1960,
Revue d'immunologie et de therapie antimicrobienne,
M E Regalado, and
B Nieves Rodríguez, and
M T Ghersy, and
M Amilachwari, and
J R Nieto, and
G Velásquez
September 1988,
Ceskoslovenska pediatrie,
M E Regalado, and
B Nieves Rodríguez, and
M T Ghersy, and
M Amilachwari, and
J R Nieto, and
G Velásquez
April 1959,
Annales de l'Institut Pasteur,
M E Regalado, and
B Nieves Rodríguez, and
M T Ghersy, and
M Amilachwari, and
J R Nieto, and
G Velásquez
March 1953,
Nederlands tijdschrift voor geneeskunde,
M E Regalado, and
B Nieves Rodríguez, and
M T Ghersy, and
M Amilachwari, and
J R Nieto, and
G Velásquez
November 1953,
The Medical journal of Australia,
