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Breaking a vicious cycle. 2013
Daniel F Hayes, and
Jeff Allen, and
Carolyn Compton, and
Gary Gustavsen, and
Debra G B Leonard, and
Robert McCormack, and
Lee Newcomer, and
Kristin Pothier, and
David Ransohoff, and
Richard L Schilsky, and
Ellen Sigal, and
Sheila E Taube, and
Sean R Tunis
University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA. hayesdf@umich.edu
Despite prodigious advances in tumor biology research, few tumor-biomarker tests have been adopted as standard clinical practice. This lack of reliable tests stems from a vicious cycle of undervaluation, resulting from inconsistent regulatory standards and reimbursement, as well as insufficient investment in research and development, scrutiny of biomarker publications by journals, and evidence of analytical validity and clinical utility. We offer recommendations designed to serve as a roadmap to break this vicious cycle and call for a national dialogue, as changes in regulation, reimbursement, investment, peer review, and guidelines development require the participation of all stakeholders.
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June 2020,
World journal of surgery,
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