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There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent test performed while ART-naive. The rate at which mutations became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue mutations (TAMs) and T215 revertants (but not T215F/Y) were found to be highly stable, with NNRTI and PI mutations being relatively less persistent. Our estimates are important for informing HIV transmission models.
Hannah Castro, and
Deenan Pillay, and
Patricia Cane, and
David Asboe, and
Valentina Cambiano, and
Andrew Phillips, and
David T Dunn, and
April 2011,
The Journal of infectious diseases,
Hannah Castro, and
Deenan Pillay, and
Patricia Cane, and
David Asboe, and
Valentina Cambiano, and
Andrew Phillips, and
David T Dunn, and
March 2015,
PLoS pathogens,
Hannah Castro, and
Deenan Pillay, and
Patricia Cane, and
David Asboe, and
Valentina Cambiano, and
Andrew Phillips, and
David T Dunn, and
January 2019,
PloS one,
Hannah Castro, and
Deenan Pillay, and
Patricia Cane, and
David Asboe, and
Valentina Cambiano, and
Andrew Phillips, and
David T Dunn, and
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PloS one,
Hannah Castro, and
Deenan Pillay, and
Patricia Cane, and
David Asboe, and
Valentina Cambiano, and
Andrew Phillips, and
David T Dunn, and
February 2019,
AIDS research and therapy,
Hannah Castro, and
Deenan Pillay, and
Patricia Cane, and
David Asboe, and
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David T Dunn, and
December 2002,
Journal of medical virology,
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Patricia Cane, and
David Asboe, and
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January 2020,
The Journal of antimicrobial chemotherapy,
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David Asboe, and
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May 2021,
Viruses,
Hannah Castro, and
Deenan Pillay, and
Patricia Cane, and
David Asboe, and
Valentina Cambiano, and
Andrew Phillips, and
David T Dunn, and
July 2014,
HIV medicine,
Hannah Castro, and
Deenan Pillay, and
Patricia Cane, and
David Asboe, and
Valentina Cambiano, and
Andrew Phillips, and
David T Dunn, and
May 2010,
AIDS (London, England),
