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The present study has investigated ultrastructural localization of anionic sites on the luminal surface of the alveolar epithelium of goat lung by direct airway instillation of cationized ferritin (CF) in the cranial lobe of the right lung through a bronchoscope. The cationic probe decorated preferentially the luminal plasmalemmal vesicles and plasmalemma proper of alveolar type I cell. This indicated the presence of highly charged anionic microdomains at these binding sites. The ligand was internalized in the free plasmalemmal vesicles of alveolar type I cell within 2 min. Heavy decoration of vesicles at 5 min of perfusion indicated that the amount of CF internalization increased with its concentration in the alveoli. It is suggested that exposure of alveolar surface to several gases of ruminal-origin induces changes in the surface charge of luminal plasmalemma of alveolar type I cells. The significance of these anionic plasmalemmal sites is discussed in relation to the adjustment of osmotic pressure gradient across the alveolar-capillary membrane of the ruminant lung.
O S Atwal, and
L Viel, and
K J Minhas
July 1981,
Journal of ultrastructure research,
O S Atwal, and
L Viel, and
K J Minhas
March 1982,
Okajimas folia anatomica Japonica,
O S Atwal, and
L Viel, and
K J Minhas
January 1990,
Acta histochemica,
O S Atwal, and
L Viel, and
K J Minhas
December 1977,
Journal of cell science,
O S Atwal, and
L Viel, and
K J Minhas
January 1982,
Cell biophysics,
O S Atwal, and
L Viel, and
K J Minhas
January 1981,
Tissue & cell,
O S Atwal, and
L Viel, and
K J Minhas
January 1981,
Current eye research,
O S Atwal, and
L Viel, and
K J Minhas
February 1983,
The Journal of pathology,
O S Atwal, and
L Viel, and
K J Minhas
January 2009,
Nanotoxicology,
O S Atwal, and
L Viel, and
K J Minhas
October 2009,
Biological & pharmaceutical bulletin,
