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Varicella-zoster virus-specific antibody responses in 50-59-year-old recipients of zoster vaccine. 2013
Myron J Levin, and
Kenneth E Schmader, and
John W Gnann, and
Shelly A McNeil, and
Timo Vesikari, and
Robert F Betts, and
Susan Keay, and
Jon E Stek, and
Nickoya D Bundick, and
Shu-Chih Su, and
Yanli Zhao, and
Xiaoming Li, and
Ivan S F Chan, and
Paula W Annunziato, and
Janie Parrino
University of Colorado Denver Anschutz Medical Campus, Aurora.
Prevaccination and 6-week postvaccination samples from the immunogenicity substudy (n = 2269) of the zoster vaccine (ZV) efficacy trial (N = 22 439) in 50-59-year-old subjects were examined for varicella-zoster virus-specific antibody responses to vaccination. The varicella-zoster virus geometric mean titer (GMT) and geometric mean fold rise were higher in ZV recipients than in placebo recipients (GMT, 660.0 vs 293.1 glycoprotein enzyme-linked immunosorbent assay units/mL [P < .001], respectively; geometric mean fold rise, 2.31 vs 1.00 [P < .025]). In each group there was a strong inverse correlation between postvaccination GMT and risk of subsequent herpes zoster. Although these data provide strong evidence that relates ZV-induced antibody and the risk of herpes zoster, a protective threshold was not determined. Clinical Trials Registration. NCT00534248.
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