BIOMAT Database Logo BIOMAT Database Logo

Schizophrenia miR-137 locus risk genotype is associated with dorsolateral prefrontal cortex hyperactivation. 2014

Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
Department of Psychiatry and Human Behavior, Functional Genomics Laboratory, University of California Irvine, Irvine, California.

BACKGROUND miR-137 dysregulation has been implicated in the etiology of schizophrenia, but its functional role remains to be determined. METHODS Functional magnetic resonance imaging scans were acquired on 48 schizophrenia patients and 63 healthy volunteers (total sample size N = 111 subjects), with similar mean age and sex distribution, while subjects performed a Sternberg Item Response Paradigm with memory loads of one, three, and five numbers. Dorsolateral prefrontal cortex (DLPFC) retrieval activation for the working memory load of three numbers, for which hyperactivation had been shown in schizophrenia patients compared with control subjects, was extracted. The genome-wide association study confirmed schizophrenia risk single nucleotide polymorphism rs1625579 (miR-137 locus) was genotyped (schizophrenia: GG n = 0, GT n = 9, TT n = 39; healthy volunteers: GG = 2, GT n = 15, and TT n = 46). Fisher's exact test examined the effect of diagnosis on rs1625579 allele frequency distribution (p = nonsignificant). Mixed model regression analyses examined the effects of diagnosis and genotype on working memory performance measures and DLPFC activation. RESULTS Patients showed significantly higher left DLPFC retrieval activation on working memory load 3, lower working memory performance, and longer response times compared with controls. There was no effect of genotype on working memory performance or response times in either group. However, individuals with the rs1625579 TT genotype had significantly higher left DLPFC activation than those with the GG/GT genotypes. CONCLUSIONS Our study suggests that the rs1625579 TT (miR-137 locus) schizophrenia risk genotype is associated with the schizophrenia risk phenotype DLPFC hyperactivation commonly considered a measure of brain inefficiency.

UI MeSH Term Description Entries
D007091 Image Processing, Computer-Assisted A technique of inputting two-dimensional or three-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer. Biomedical Image Processing,Computer-Assisted Image Processing,Digital Image Processing,Image Analysis, Computer-Assisted,Image Reconstruction,Medical Image Processing,Analysis, Computer-Assisted Image,Computer-Assisted Image Analysis,Computer Assisted Image Analysis,Computer Assisted Image Processing,Computer-Assisted Image Analyses,Image Analyses, Computer-Assisted,Image Analysis, Computer Assisted,Image Processing, Biomedical,Image Processing, Computer Assisted,Image Processing, Digital,Image Processing, Medical,Image Processings, Medical,Image Reconstructions,Medical Image Processings,Processing, Biomedical Image,Processing, Digital Image,Processing, Medical Image,Processings, Digital Image,Processings, Medical Image,Reconstruction, Image,Reconstructions, Image
D008297 Male Males
D008570 Memory, Short-Term Remembrance of information for a few seconds to hours. Immediate Recall,Memory, Immediate,Working Memory,Memory, Shortterm,Immediate Memories,Immediate Memory,Immediate Recalls,Memories, Immediate,Memories, Short-Term,Memories, Shortterm,Memory, Short Term,Recall, Immediate,Recalls, Immediate,Short-Term Memories,Short-Term Memory,Shortterm Memories,Shortterm Memory,Working Memories
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009483 Neuropsychological Tests Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury. Aphasia Tests,Cognitive Test,Cognitive Testing,Cognitive Tests,Memory for Designs Test,Neuropsychological Testing,AX-CPT,Behavioral Assessment of Dysexecutive Syndrome,CANTAB,Cambridge Neuropsychological Test Automated Battery,Clock Test,Cognitive Function Scanner,Continuous Performance Task,Controlled Oral Word Association Test,Delis-Kaplan Executive Function System,Developmental Neuropsychological Assessment,Hooper Visual Organization Test,NEPSY,Neuropsychologic Tests,Neuropsychological Test,Paced Auditory Serial Addition Test,Repeatable Battery for the Assessment of Neuropsychological Status,Rey-Osterrieth Complex Figure,Symbol Digit Modalities Test,Test of Everyday Attention,Test, Neuropsychological,Tests, Neuropsychological,Tower of London Test,Neuropsychologic Test,Test, Cognitive,Testing, Cognitive,Testing, Neuropsychological,Tests, Cognitive
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D005260 Female Females
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

Related Publications

Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex.
July 2020, Psychological medicine,
Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
Schizophrenia-associated MicroRNA-Gene Interactions in the Dorsolateral Prefrontal Cortex.
December 2019, Genomics, proteomics & bioinformatics,
Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
The dorsolateral prefrontal cortex, schizophrenia and PET.
January 1992, Journal of neural transmission. Supplementum,
Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.
January 2008, Schizophrenia research,
Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding.
June 2009, NeuroImage,
Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
Left dorsolateral prefrontal cortex dysfunction in medication-naive schizophrenia.
October 2010, Schizophrenia research,
Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
Dorsolateral prefrontal cortex volume in patients with deficit or nondeficit schizophrenia.
June 2012, Progress in neuro-psychopharmacology & biological psychiatry,
Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
Self-harm in schizophrenia is associated with dorsolateral prefrontal and posterior cingulate activity.
August 2015, Progress in neuro-psychopharmacology & biological psychiatry,
Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia.
November 2016, Schizophrenia research,
Theo G M van Erp, and Ilaria Guella, and Marquis P Vawter, and Jessica Turner, and Gregory G Brown, and Gregory McCarthy, and Douglas N Greve, and Gary H Glover, and Vince D Calhoun, and Kelvin O Lim, and Juan R Bustillo, and Aysenil Belger, and Judith M Ford, and Daniel H Mathalon, and Michele Diaz, and Adrian Preda, and Dana Nguyen, and Fabio Macciardi, and Steven G Potkin
Neuroinflammation in the dorsolateral prefrontal cortex in elderly chronic schizophrenia.
March 2019, European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
Copied contents to your clipboard!