Mirabegron for male lower urinary tract symptoms. 2013

Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
Departamento de Urología, Hospital Universitario de la Universidad Autónoma de Nuevo León, Av. Madero Y Gonzalitos S/N Mitras Centro, C.P. 64460, Monterrey, Nuevo León, Mexico, osuarezfl@gmail.com.

Benign prostatic hyperplasia (BPH) is a common cause of lower urinary tract symptoms (LUTS) in men. Patients with BPH often present with a combination of obstructive and overactive bladder (OAB) symptoms. It is postulated that bladder outlet obstruction (BOO) from BPH results in concomitant OAB symptoms through ischemic induced variations in the response to neurotransmitters of both the detrusor and the urothelium. This altered response leads to the pathologic activation of the micturition reflex, generating sensory dysfunction and involuntary bladder contractions. Alpha-1 adrenoceptor antagonists (alpha-blockers) and 5-alpha reductase inhibitors (5-ARIs) are commonly used to treat the BOO caused by BPH. Anticholinergic agents are frequently used to treat concurrently OAB symptoms caused by the BOO. Unfortunately, anticholinergic medications demonstrate bothersome side effects and a theoretical risk of urinary retention. Basic science and clinical research has led to the development of a new class of pharmaceuticals for the treatment of overactive bladder with diminished risk of urinary retention and lacking many anticholinergic side effects. This novel compound, mirabegron (Mybertriq, Astellas Pharma US, Inc.), is a β₃-adrenoceptor agonist and represents a promising new class of oral agents designed for the treatment of OAB symptoms, with minimal effect on voiding.

UI MeSH Term Description Entries
D008297 Male Males
D011470 Prostatic Hyperplasia Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both. Adenoma, Prostatic,Benign Prostatic Hyperplasia,Prostatic Adenoma,Prostatic Hyperplasia, Benign,Prostatic Hypertrophy,Prostatic Hypertrophy, Benign,Adenomas, Prostatic,Benign Prostatic Hyperplasias,Benign Prostatic Hypertrophy,Hyperplasia, Benign Prostatic,Hyperplasia, Prostatic,Hyperplasias, Benign Prostatic,Hypertrophies, Prostatic,Hypertrophy, Benign Prostatic,Hypertrophy, Prostatic,Prostatic Adenomas,Prostatic Hyperplasias, Benign,Prostatic Hypertrophies
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000083 Acetanilides Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA. Acetylanilines,N-Phenylacetamides
D013844 Thiazoles Heterocyclic compounds where the ring system is composed of three CARBON atoms, a SULFUR and NITROGEN atoms. Thiazole
D053158 Nocturia Frequent URINATION at night that interrupts sleep. It is often associated with outflow obstruction, DIABETES MELLITUS, or bladder inflammation (CYSTITIS). Nycturia
D053201 Urinary Bladder, Overactive Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. URINARY INCONTINENCE may or may not be present. Overactive Detrusor,Bladder, Overactive,Overactive Bladder,Overactive Detrusor Function,Overactive Urinary Bladder,Detrusor Function, Overactive,Detrusor, Overactive
D053448 Prostatism Lower urinary tract symptom, such as slow urinary stream, associated with PROSTATIC HYPERPLASIA in older men.
D058667 Adrenergic beta-3 Receptor Agonists Compounds that bind to and activate ADRENERGIC BETA-3 RECEPTORS. Adrenergic beta-3 Agonists,Adrenergic beta-3 Receptor Agonist,Adrenergic beta3-Agonists,Adrenergic beta 3 Agonists,Adrenergic beta 3 Receptor Agonist,Adrenergic beta 3 Receptor Agonists,Adrenergic beta3 Agonists,Agonists, Adrenergic beta-3,beta-3 Agonists, Adrenergic,beta3-Agonists, Adrenergic
D058668 Adrenergic alpha-1 Receptor Antagonists Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. Adrenergic alpha-1 Antagonists,Adrenergic alpha-1 Receptor Blockers,Adrenergic alpha1-Antagonists,alpha-1 Adrenergic Blocking Agents,alpha1-Adrenergic Antagonists,alpha1-Adrenoceptor Blocker,Adrenergic alpha 1 Antagonists,Adrenergic alpha 1 Receptor Antagonists,Adrenergic alpha 1 Receptor Blockers,Adrenergic alpha1 Antagonists,Antagonists, alpha1-Adrenergic,alpha 1 Adrenergic Blocking Agents,alpha-1 Antagonists, Adrenergic,alpha1 Adrenergic Antagonists,alpha1 Adrenoceptor Blocker,alpha1-Antagonists, Adrenergic

Related Publications

Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
June 2019, Current bladder dysfunction reports,
Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
October 2009, International journal of urology : official journal of the Japanese Urological Association,
Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
November 2007, International journal of clinical practice,
Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
December 2012, Der Urologe. Ausg. A,
Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
January 2011, Current opinion in urology,
Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
February 2013, Der Urologe. Ausg. A,
Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
September 2003, Connecticut medicine,
Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
January 2013, International journal of urology : official journal of the Japanese Urological Association,
Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
September 2022, Panminerva medica,
Oscar Suarez, and David Osborn, and Melissa Kaufman, and W Stuart Reynolds, and Roger Dmochowski
June 2013, Expert opinion on pharmacotherapy,
Copied contents to your clipboard!