Biomaterial Database

Mechanical behavior of bovine nasal cartilage under static and dynamic loading. 2013

Vera Colombo, and Michala Cadová, and Luigi M Gallo

Clinic of Masticatory Disorders, Removable Prosthodontics, Geriatric and Special Care Dentistry, Center of Dental Medicine, University of Zurich, Switzerland. vera.colombo@zzm.uzh.ch

Abnormal mechanical loading may trigger cartilage degeneration associated with osteoarthritis. Tissue response to load has been the subject of several in vitro studies. However, simple stimuli were often applied, not fully mimicking the complex in vivo conditions. Therefore, a rolling/plowing explant test system (RPETS) was developed to replicate the combined in vivo loading patterns. In this work we investigated the mechanical behavior of bovine nasal septum (BNS) cartilage, selected as tissue approximation for experiments with RPETS, under static and dynamic loading. Biphasic material properties were determined and compared with those of other cartilaginous tissues. Furthermore, dynamic loading in plowing modality was performed to determine dynamic response and experimental results were compared with analytical models and Finite Elements (FE) computations. Results showed that BNS cartilage can be modeled as a biphasic material with Young's modulus E=2.03 ± 0.7 MPa, aggregate modulus HA=2.35 ± 0.7 MPa, Poisson's ratio ν=0.24 ± 0.07, and constant hydraulic permeability k0=3.0 ± 1.3 × 10(-15)m(4)(Ns)(-1). Furthermore, dynamic analysis showed that plowing induces macroscopic reactions in the tissue, proportionally to the applied loading force. The comparison among analytical, FE analysis and experimental results showed that predicted tangential forces and sample deformation lay in the range of variation of experimental results for one specific experimental condition. In conclusion, mechanical properties of BNS cartilage under both static and dynamic compression were assessed, showing that this tissue behave as a biphasic material and has a viscoelastic response to dynamic forces.

UI	MeSH Term	Description	Entries
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D002417	Cattle	Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.	Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013314	Stress, Mechanical	A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.	Mechanical Stress,Mechanical Stresses,Stresses, Mechanical
D055119	Elastic Modulus	Numerical expression indicating the measure of stiffness in a material. It is defined by the ratio of stress in a unit area of substance to the resulting deformation (strain). This allows the behavior of a material under load (such as bone) to be calculated.	Young Modulus,Modulus of Elasticity,Young's Modulus,Elasticity Modulus,Modulus, Elastic,Modulus, Young,Modulus, Young's,Youngs Modulus
D055171	Nasal Cartilages	Hyaline cartilages in the nose. There are five major nasal cartilages including two lateral, two alar, and one septal.	Alar Nasal Cartilages,Lateral Nasal Cartilages,Septal Nasal Cartilage,Alar Nasal Cartilage,Cartilage, Alar Nasal,Cartilage, Lateral Nasal,Cartilage, Nasal,Cartilage, Septal Nasal,Cartilages, Alar Nasal,Cartilages, Lateral Nasal,Cartilages, Nasal,Cartilages, Septal Nasal,Lateral Nasal Cartilage,Nasal Cartilage,Nasal Cartilage, Alar,Nasal Cartilage, Lateral,Nasal Cartilage, Septal,Nasal Cartilages, Alar,Nasal Cartilages, Lateral,Nasal Cartilages, Septal,Septal Nasal Cartilages
D019245	Compressive Strength	The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)	Compressive Strengths,Strength, Compressive,Strengths, Compressive
D020342	Finite Element Analysis	A computer based method of simulating or analyzing the behavior of structures or components.	Analysis, Finite Element,Analyses, Finite Element,Element Analyses, Finite,Element Analysis, Finite,Finite Element Analyses