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Reserpine (10 mg/kp i.p.) increased the activities of the enzymes tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase, but not dopa decarboxylase, 2- to 3-fold in the nucleus locus ceruleus of rat brain. The TH response was dose-dependent, reached a maximum by 48 hours and recovered by 3 weeks. The increased activities of TH and dopamine-beta-hydroylase were shown by immunotitration with specific antibodies to each enzyme to be due entirely to increased accumulation of specific enzyme protein. At a time when the reserpine-elicited accumulation of TH was increased 300% in the locus ceruleus, activity of the enzyme only increased 20% in hypothalamus and not at all in substantia nigra or caudate nucleus. Reserpine increased the accumulation of TH, primarily in the cell bodies and to a far less degree in the terminals of neurons of locus ceruleus but not in dopaminergic neurons of the nigrostriatal system. The time course of enzyme accumulation parallels that of depletion of monoamines in brain.
D J Reis, and
T H Joh, and
R A Ross
April 1981,
Experimental neurology,
D J Reis, and
T H Joh, and
R A Ross
March 1975,
Brain research,
D J Reis, and
T H Joh, and
R A Ross
February 1976,
Psychopharmacologia,
D J Reis, and
T H Joh, and
R A Ross
January 1975,
Psychopharmacology communications,
D J Reis, and
T H Joh, and
R A Ross
April 1973,
Clinical science,
D J Reis, and
T H Joh, and
R A Ross
March 1992,
European journal of pharmacology,
D J Reis, and
T H Joh, and
R A Ross
January 1981,
Journal of psychosomatic research,
D J Reis, and
T H Joh, and
R A Ross
November 1976,
Neuroscience letters,
D J Reis, and
T H Joh, and
R A Ross
November 1981,
Journal of the autonomic nervous system,
D J Reis, and
T H Joh, and
R A Ross
February 1981,
Brain research bulletin,
