BIOMAT Database Logo BIOMAT Database Logo

GnRH receptor antagonists for prostate cancer. 2013

Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
Medical University of South Carolina, Charleston, USA.

GnRH receptor antagonists can reduce testosterone levels without the adverse reactions caused by other drugs used to treat prostate cancer. These drugs also offer hope for prolonged control of metastasis.

UI MeSH Term Description Entries
D007987 Gonadotropin-Releasing Hormone A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND. FSH-Releasing Hormone,GnRH,Gonadoliberin,Gonadorelin,LH-FSH Releasing Hormone,LHRH,Luliberin,Luteinizing Hormone-Releasing Hormone,Cystorelin,Dirigestran,Factrel,Gn-RH,Gonadorelin Acetate,Gonadorelin Hydrochloride,Kryptocur,LFRH,LH-RH,LH-Releasing Hormone,LHFSH Releasing Hormone,LHFSHRH,FSH Releasing Hormone,Gonadotropin Releasing Hormone,LH FSH Releasing Hormone,LH Releasing Hormone,Luteinizing Hormone Releasing Hormone,Releasing Hormone, LHFSH
D008297 Male Males
D011471 Prostatic Neoplasms Tumors or cancer of the PROSTATE. Cancer of Prostate,Prostate Cancer,Cancer of the Prostate,Neoplasms, Prostate,Neoplasms, Prostatic,Prostate Neoplasms,Prostatic Cancer,Cancer, Prostate,Cancer, Prostatic,Cancers, Prostate,Cancers, Prostatic,Neoplasm, Prostate,Neoplasm, Prostatic,Prostate Cancers,Prostate Neoplasm,Prostatic Cancers,Prostatic Neoplasm
D011966 Receptors, LHRH Receptors with a 6-kDa protein on the surfaces of cells that secrete LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE, usually in the adenohypophysis. LUTEINIZING HORMONE-RELEASING HORMONE binds to these receptors, is endocytosed with the receptor and, in the cell, triggers the release of LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE by the cell. These receptors are also found in rat gonads. INHIBINS prevent the binding of GnRH to its receptors. GnRH Receptors,Gonadoliberin Receptors,Gonadorelin Receptors,Gonadotropin Releasing-Hormone Receptors,LHFSHRH Receptors,LHRH Receptors,Luliberin Receptors,Receptors, GnRH,Receptors, Gonadoliberin,Receptors, Gonadorelin,Receptors, Luliberin,Follicle Stimulating Hormone-Releasing Hormone Receptors,GnRH Receptor,Gonadorelin Receptor,Gonadotropin-Releasing Hormone Receptor,LHRH Receptor,Luteinizing Hormone Releasing Hormone Receptors,Luteinizing Hormone Releasing-Hormone Receptor,Receptor, LHRH,Receptors, Gonadotropin Releasing-Hormone,Receptors, LHFSHRH,Follicle Stimulating Hormone Releasing Hormone Receptors,Gonadotropin Releasing Hormone Receptor,Gonadotropin Releasing Hormone Receptors,Hormone Receptor, Gonadotropin-Releasing,Luteinizing Hormone Releasing Hormone Receptor,Receptor, GnRH,Receptor, Gonadorelin,Receptor, Gonadotropin-Releasing Hormone,Receptors, Gonadotropin Releasing Hormone,Releasing-Hormone Receptors, Gonadotropin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
Will GnRH antagonists improve prostate cancer treatment?
January 2009, Trends in endocrinology and metabolism: TEM,
Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
[GnRH antagonists--a new therapy option for advanced prostate cancer].
May 2009, Aktuelle Urologie,
Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
Prostate cancer: Cardiovascular morbidity risk lower for ADT with GnRH antagonists than GnRH agonists.
December 2013, Nature reviews. Urology,
Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
Development of GnRH antagonists for prostate cancer: new approaches to treatment.
January 2000, The oncologist,
Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
GnRH antagonists in the treatment of advanced prostate cancer.
April 2010, The Canadian journal of urology,
Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
Embryo implantation and GnRH antagonists: GnRH antagonists do not activate the GnRH receptor.
September 2000, Human reproduction (Oxford, England),
Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
Androgen receptor antagonists for prostate cancer therapy.
August 2014, Endocrine-related cancer,
Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
Non-peptidic GnRH receptor antagonists.
November 2004, Current medicinal chemistry,
Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
Current and emerging gonadotropin-releasing hormone (GnRH) antagonists for the treatment of prostate cancer.
December 2021, Expert opinion on pharmacotherapy,
Emily Patrick, and Melissa Whitson, and Amy Smith, and Jamin Parnell, and Suzanne E Thomas, and Clint C Blankenship
Embryo implantation and GnRH antagonists: the search for the human placental GnRH receptor.
February 2001, Human reproduction (Oxford, England),
Copied contents to your clipboard!