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[Identification of origins of marker chromosomes using fluorescence in situ hybridization]. 2013
Qiong Wu, and
Yu-lin Zhou, and
Hui Kong, and
Huan Zeng, and
Hui-nan Wu, and
Yan-yan Sheng, and
Chao-yi Yang, and
Yun-sheng Ge, and
Mei-jiao Cai, and
Ting-ting Huang, and
Jia-yan Chen, and
Xia-olu Chen, and
Dong-xing Zhou, and
Xin-gli Huang
Xiamen Prenatal Diagnosis Center, Xiamen Maternal & Child Health Care Hospital, Xiamen, Fujian 361003, P. R. China. zhou_yulin@126.com.
OBJECTIVE To assess the value of fluorescence in situ hybridization (FISH) and bacterial artificial chromosome FISH (BAC-FISH) for the diagnosis for patients with marker chromosomes. METHODS Sixteen patients with marker chromosomes were analyzed with technologies including GTG-banding, Q-banding, multiplex FISH and BAC-FISH. RESULTS The marker chromosomes in the 16 patients were verified as der(Y) (2 cases), psu dic(Y) (1 case), psu dic(15) (1 case), dic(15) (1 case), del(Y) (1 case), r(X) (5 cases), i(14 or 22) (2 cases), i(18) (1 case). CONCLUSIONS FISH and BAC-FISH can both verify the origin of marker chromosomes and provide accurate information for the diagnosis and treatment of patients.
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