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Trimethyltin (TMT) is a neurotoxicant known to alter auditory function. The present study was designed to compare TMT-induced auditory dysfunction using behavioral, electrophysiological, and anatomical techniques. Adult male Long-Evans hooded rats (n = 9-12/group) were acutely exposed to saline, 3, 5, or 7 mg/kg TMT. Auditory thresholds were determined 11 weeks postdosing for 5- and 40-kHz tones using reflex modification of the auditory startle response (ASR). Brainstem auditory evoked response (BAER) thresholds were determined for 5-, 40-, and 80-kHz tonal stimuli 9 weeks postdosing. Cochlear histology was assessed at 13 weeks postdosing. Functional endpoints demonstrated a high-frequency hearing loss. ASR thresholds for 40-kHz tones were elevated 25-35 dB in all dosage groups. BAER thresholds for 40- and 80-kHz tones were elevated 30-50 dB in the 5 and 7 mg/kg groups. Organ of Corti surface preparations revealed a pattern of damage suggesting classical ototoxicity. That is, outer hair cells died preferentially in regions associated with high-frequency hearing, in a dosage-dependent manner from base to apex. These data demonstrate the utility of the ASR and BAER in detecting functional alterations in audition and indicate that TMT-induced high-frequency hearing loss is associated with cochlear damage.
K M Crofton, and
K F Dean, and
M G Ménache, and
R Janssen
January 1991,
Neurotoxicology and teratology,
K M Crofton, and
K F Dean, and
M G Ménache, and
R Janssen
September 2006,
Hearing research,
K M Crofton, and
K F Dean, and
M G Ménache, and
R Janssen
June 2014,
Auris, nasus, larynx,
K M Crofton, and
K F Dean, and
M G Ménache, and
R Janssen
August 1990,
Toxicology and applied pharmacology,
K M Crofton, and
K F Dean, and
M G Ménache, and
R Janssen
February 1996,
Toxicology and applied pharmacology,
K M Crofton, and
K F Dean, and
M G Ménache, and
R Janssen
November 1991,
Hearing research,
K M Crofton, and
K F Dean, and
M G Ménache, and
R Janssen
January 1997,
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery,
K M Crofton, and
K F Dean, and
M G Ménache, and
R Janssen
January 1979,
Archives of oto-rhino-laryngology,
K M Crofton, and
K F Dean, and
M G Ménache, and
R Janssen
March 1992,
Hearing research,
K M Crofton, and
K F Dean, and
M G Ménache, and
R Janssen
September 2016,
Journal of otology,
