BIOMAT Database Logo BIOMAT Database Logo

Caught in the act. 2013

Hermann-Josef Meyer, and Michael Rape
is in the Department of Molecular and Cell Biology , University of California, Berkeley , Berkeley , United States hermannmeyer@berkeley.edu.

The crystal structure of a HECT E3 enzyme has been captured as it transfers ubiquitin to a target protein, revealing the dramatic changes in shape that enable it to modify particular residues in its targets.

UI MeSH Term Description Entries
D008239 Lysine An essential amino acid. It is often added to animal feed. Enisyl,L-Lysine,Lysine Acetate,Lysine Hydrochloride,Acetate, Lysine,L Lysine
D044767 Ubiquitin-Protein Ligases A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes. Ubiquitin-Protein Ligase,E3 Ligase,E3 Ubiquitin Ligase,Ubiquitin Ligase E3,Ubiquitin-Protein Ligase E3,Ligase E3, Ubiquitin,Ligase E3, Ubiquitin-Protein,Ligase, E3,Ligase, E3 Ubiquitin,Ligase, Ubiquitin-Protein,Ligases, Ubiquitin-Protein,Ubiquitin Ligase, E3,Ubiquitin Protein Ligase,Ubiquitin Protein Ligase E3,Ubiquitin Protein Ligases
D025801 Ubiquitin A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell. APF-1,ATP-Dependent Proteolysis Factor 1,HMG-20,High Mobility Protein 20,Ubiquitin, Human,ATP Dependent Proteolysis Factor 1,Human Ubiquitin

Related Publications

Hermann-Josef Meyer, and Michael Rape
Caught in the act.
August 2018, Nature chemical biology,
Hermann-Josef Meyer, and Michael Rape
Caught in the act.
January 1997, Nursing times,
Hermann-Josef Meyer, and Michael Rape
Caught in the act!
December 1989, American journal of kidney diseases : the official journal of the National Kidney Foundation,
Hermann-Josef Meyer, and Michael Rape
Caught in the act.
January 1994, Elderly care,
Hermann-Josef Meyer, and Michael Rape
Caught in the act.
January 2023, Nature chemical biology,
Hermann-Josef Meyer, and Michael Rape
Caught in the act.
March 2018, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver,
Hermann-Josef Meyer, and Michael Rape
The Children Act: caught in the act.
January 1991, Nursing standard (Royal College of Nursing (Great Britain) : 1987),
Hermann-Josef Meyer, and Michael Rape
Neurobiology: caught in the act.
July 2003, Nature,
Hermann-Josef Meyer, and Michael Rape
Photochemistry: Caught in the act.
May 2017, Nature chemistry,
Hermann-Josef Meyer, and Michael Rape
Fluctuations caught in the act.
March 2000, Nature,
Copied contents to your clipboard!