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The contribution of different rat organs to the synthesis of ceruloplasmin (Cp) was studied. Dot hybridization with the use of the Cp cDNA probe revealed Cp mRNA sequences in RNA preparations from liver, heart, kidney as well as from different divisions of brain, the concentration of Cp mRNA sequences being maximal in the liver. Polyribosomes isolated from these organs effectively synthesized Cp in a cell-free system derived from rabbit reticulocytes. After in vivo pulse labeling, the newly formed radioactive Cp was detected in the membrane fractions from all these organs. The newly formed Cp was concentrated within the membranes of the Golgi complex of various organs where it was revealed by different immunochemical techniques. Experiments with isolation of the liver from the systemic circulation showed that the liver is the only organ secreting Cp into the blood stream. It was suggested that mammalian tissues contain at least two molecular forms of Cp, i. e., circulatory and intracellular ones.
V S Gaĭtskhoki, and
O V Voronina, and
V V Denezhkina, and
M G Pliss, and
L V Puchkova, and
A L Shvartsman, and
S A Neĭfakh
November 1990,
Biokhimiia (Moscow, Russia),
V S Gaĭtskhoki, and
O V Voronina, and
V V Denezhkina, and
M G Pliss, and
L V Puchkova, and
A L Shvartsman, and
S A Neĭfakh
March 1995,
Biochimica et biophysica acta,
V S Gaĭtskhoki, and
O V Voronina, and
V V Denezhkina, and
M G Pliss, and
L V Puchkova, and
A L Shvartsman, and
S A Neĭfakh
July 1998,
Wei sheng yan jiu = Journal of hygiene research,
V S Gaĭtskhoki, and
O V Voronina, and
V V Denezhkina, and
M G Pliss, and
L V Puchkova, and
A L Shvartsman, and
S A Neĭfakh
January 2013,
Molekuliarnaia biologiia,
V S Gaĭtskhoki, and
O V Voronina, and
V V Denezhkina, and
M G Pliss, and
L V Puchkova, and
A L Shvartsman, and
S A Neĭfakh
June 1996,
Biochimica et biophysica acta,
V S Gaĭtskhoki, and
O V Voronina, and
V V Denezhkina, and
M G Pliss, and
L V Puchkova, and
A L Shvartsman, and
S A Neĭfakh
May 1998,
Cell and tissue research,
V S Gaĭtskhoki, and
O V Voronina, and
V V Denezhkina, and
M G Pliss, and
L V Puchkova, and
A L Shvartsman, and
S A Neĭfakh
July 1994,
Transplant international : official journal of the European Society for Organ Transplantation,
V S Gaĭtskhoki, and
O V Voronina, and
V V Denezhkina, and
M G Pliss, and
L V Puchkova, and
A L Shvartsman, and
S A Neĭfakh
February 1991,
The American journal of physiology,
V S Gaĭtskhoki, and
O V Voronina, and
V V Denezhkina, and
M G Pliss, and
L V Puchkova, and
A L Shvartsman, and
S A Neĭfakh
January 1981,
Molekuliarnaia biologiia,
V S Gaĭtskhoki, and
O V Voronina, and
V V Denezhkina, and
M G Pliss, and
L V Puchkova, and
A L Shvartsman, and
S A Neĭfakh
January 1982,
Vestnik Akademii meditsinskikh nauk SSSR,
