Supplementation with natural forms of vitamin E augments antigen-specific TH1-type immune response to tetanus toxoid. 2013

Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
Pathology Division, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Wilayah Persekutuan, Malaysia. ammu_radhakrishnan@imu.edu.my

This study compared the ability of three forms of vitamin E [tocotrienol-rich fraction (TRF), alpha-tocopherol (α-T), and delta-tocotrienol (δ-T3)] to enhance immune response to tetanus toxoid (TT) immunisation in a mouse model. Twenty BALB/c mice were divided into four groups of five mice each. The mice were fed with the different forms of vitamin E (1 mg) or vehicle daily for two weeks before they were given the TT vaccine [4 Lf] intramuscularly (i.m.). Booster vaccinations were given on days 28 and 42. Serum was collected (days 0, 28, and 56) to quantify anti-TT levels. At autopsy, splenocytes harvested were cultured with TT or mitogens. The production of anti-TT antibodies was augmented (P < 0.05) in mice that were fed with δ-T3 or TRF compared to controls. The production of IFN-γ and IL-4 by splenocytes from the vitamin E treated mice was significantly (P < 0.05) higher than that from controls. The IFN-γ production was the highest in animals supplemented with δ-T3 followed by TRF and finally α-T. Production of TNF-α was suppressed in the vitamin E treated group compared to vehicle-supplemented controls. Supplementation with δ-T3 or TRF can enhance immune response to TT immunisation and production of cytokines that promote cell-mediated (TH1) immune response.

UI MeSH Term Description Entries
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000907 Antibodies, Bacterial Immunoglobulins produced in a response to BACTERIAL ANTIGENS. Bacterial Antibodies
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D013745 Tetanus Toxoid Tetanus Vaccine,Toxoid, Tetanus,Vaccine, Tetanus
D014810 Vitamin E A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
D015847 Interleukin-4 A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells. B-Cell Growth Factor-I,B-Cell Stimulatory Factor-1,Binetrakin,IL-4,Mast Cell Growth Factor-2,B Cell Stimulatory Factor-1,B-Cell Growth Factor-1,B-Cell Proliferating Factor,B-Cell Stimulating Factor-1,B-Cell Stimulatory Factor 1,BCGF-1,BSF-1,IL4,MCGF-2,B Cell Growth Factor 1,B Cell Growth Factor I,B Cell Proliferating Factor,B Cell Stimulating Factor 1,B Cell Stimulatory Factor 1,Interleukin 4,Mast Cell Growth Factor 2
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D056704 Adaptive Immunity Protection from an infectious disease agent that is mediated by B- and T- LYMPHOCYTES following exposure to specific antigen, and characterized by IMMUNOLOGIC MEMORY. It can result from either previous infection with that agent or vaccination (IMMUNITY, ACTIVE), or transfer of antibody or lymphocytes from an immune donor (IMMUNIZATION, PASSIVE). Acquired Immunity,Hybrid Immunity,Adaptive Immune Response,Adoptive Immunity,Immunity, Adaptive,Hybrid Immunities,Immune Response, Adaptive,Immunity, Acquired,Immunity, Adoptive,Immunity, Hybrid,Response, Adaptive Immune
D018417 Th1 Cells A subset of helper-inducer T-lymphocytes which synthesize and secrete INTERLEUKIN-2; INTERFERON-GAMMA; and INTERLEUKIN-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions. T Helper 1 Cells,TH-1 Cells,Type 1 Helper T Cells,Cell, TH-1,Cell, Th1,Cells, TH-1,Cells, Th1,TH 1 Cells,TH-1 Cell,Th1 Cell

Related Publications

Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
July 2000, Vaccine,
Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
January 1996, The Journal of infectious diseases,
Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
March 2011, European journal of clinical nutrition,
Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
December 1979, The Onderstepoort journal of veterinary research,
Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
January 1975, Nihon saikingaku zasshi. Japanese journal of bacteriology,
Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
January 1969, Studii si cercetari de medicina interna,
Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
January 1985, Dermatologische Monatschrift,
Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
April 2006, Vaccine,
Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
September 2003, Journal of veterinary medicine. B, Infectious diseases and veterinary public health,
Ammu Kutty Radhakrishnan, and Dashayini Mahalingam, and Kanga Rani Selvaduray, and Kalanithi Nesaretnam
November 1996, The Journal of clinical investigation,
Copied contents to your clipboard!