Pathological correlates of magnetic resonance imaging texture heterogeneity in multiple sclerosis. 2013

Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
Department of Radiology, University of Calgary, Calgary, Alberta; Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta.

OBJECTIVE To analyze the texture of T2-weighted magnetic resonance imaging (MRI) of postmortem multiple sclerosis (MS) brain, and to determine whether and how MRI texture correlates with tissue pathology. METHODS Ten brain samples from 3 subjects with MS were examined. Areas of complete, partial, or no loss of Luxol fast blue (myelin) and Bielschowsky (axons) staining were marked on histological images, and matched on corresponding MRI as lesions, diffusely abnormal white matter (DAWM), and normal-appearing white matter (NAWM). The number of CD45(+) cells (inflammation) was also counted. MRI texture was computed using polar Stockwell transform and compared to histology. RESULTS Thirty-four lesions, 17 DAWM regions, and 36 NAWM regions were identified. After mixed effects modeling, MRI texture heterogeneity was greater in lesions than in DAWM (p < 0.001) and NAWM (p < 0.001), and was greater in DAWM than in NAWM (p < 0.001); the number of CD45+ cells was greater in both lesions (p < 0.001) and DAWM (p = 0.005) than in NAWM. In MRI, a gradient of texture heterogeneity was detected in lesions, with gradual tapering toward perilesional NAWM. Moreover, besides univariate correlation with histological markers, texture heterogeneity correlated independently with normalized myelin density (p < 0.01) when random effects were considered. Within sample, MRI texture correlated with myelin and axonal density in 7 of 10 samples (p < 0.01). CONCLUSIONS Texture analysis performed on routine clinical magnetic resonance images may be a potential measure of tissue integrity. Tissues with more severe myelin and axonal pathology are associated with greater texture heterogeneity.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009103 Multiple Sclerosis An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D009186 Myelin Sheath The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem. Myelin,Myelin Sheaths,Sheath, Myelin,Sheaths, Myelin
D009413 Nerve Fibers, Myelinated A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves. A Fibers,B Fibers,Fiber, Myelinated Nerve,Fibers, Myelinated Nerve,Myelinated Nerve Fiber,Myelinated Nerve Fibers,Nerve Fiber, Myelinated
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002452 Cell Count The number of CELLS of a specific kind, usually measured per unit volume or area of sample. Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D005260 Female Females

Related Publications

Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
July 1987, Archives of neurology,
Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
September 2012, Journal of neuropathology and experimental neurology,
Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
August 1999, Journal of neurology, neurosurgery, and psychiatry,
Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
September 2021, Annals of neurology,
Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
January 1992, The Journal of neuropsychiatry and clinical neurosciences,
Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
March 2002, NeuroImage,
Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
April 1993, Journal of the neurological sciences,
Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
January 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
November 2014, Multiple sclerosis and related disorders,
Yunyan Zhang, and G R Wayne Moore, and Cornelia Laule, and Thorarin A Bjarnason, and Piotr Kozlowski, and Anthony Traboulsee, and David K B Li
March 2015, Global journal of health science,
Copied contents to your clipboard!