-transparent.png){kind=logo}
Fluorinated pseudopeptide analogues of the neuropeptide 26RFa: synthesis, biological, and structural studies. 2013
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
UMR 6014 COBRA, INSA and University of Rouen, IRCOF, 1 rue Tesnière, 76130 Mont-Saint-Aignan (France).
A series of four fluorinated dipeptide analogues each containing a fluoro-olefin moiety as peptide bond surrogate has been designed and synthesized. These motifs have been successfully introduced into the bioactive C-terminal heptapeptide of the neuropeptide 26RFa by conventional SPPS. We then evaluated the ability of the generated pseudopeptides to increase [Ca²⁺](i) in GPR103-transfected cells. For these fluorinated analogues, greater stability in human serum was observed. Their conformations were also investigated, leading to the valuable identification of differences depending on the position of the fluoro-olefin moiety in the sequence.
Related Publications
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
July 2009,
Bioorganic & medicinal chemistry,
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
February 1986,
Journal of medicinal chemistry,
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
June 2020,
ACS central science,
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
September 1992,
Journal of medicinal chemistry,
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
May 2008,
Journal of medicinal chemistry,
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
June 2007,
Chemistry & biodiversity,
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
December 1980,
Biochemical and biophysical research communications,
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
February 2009,
Journal of medicinal chemistry,
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
July 2003,
Bioorganic & medicinal chemistry letters,
Camille Pierry, and
Samuel Couve-Bonnaire, and
Laure Guilhaudis, and
Cindy Neveu, and
Amélie Marotte, and
Benjamin Lefranc, and
Dominique Cahard, and
Isabelle Ségalas-Milazzo, and
Jérôme Leprince, and
Xavier Pannecoucke
February 2019,
Organic & biomolecular chemistry,
