If the rates, K(x,y), at which particles of size x coalesce with particles of size y is known, then the mean-field evolution of the particle size distribution of an ensemble of irreversibly coalescing particles is described by the Smoluchowski equation. We study the corresponding inverse problem which aims to determine the coalescence rates K(x,y) from measurements of the particle size distribution. We assume that K(x,y) is a homogeneous function of its arguments, a case which occurs commonly in practice. The problem of determining K(x,y), a function to two variables, then reduces to the simpler problem of determining a function of a single variable plus two exponents, μ and ν, which characterize the scaling properties of K(x,y). The price of this simplification is that the resulting least-squares problem is nonlinear in the exponents μ and ν. We demonstrate the effectiveness of the method on a selection of coalescence problems arising in polymer physics, cloud science, and astrophysics. The applications include examples in which the particle size distribution is stationary owing to the presence of sources and sinks of particles and examples in which the particle size distribution is undergoing self-similar relaxation in time.