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The objective of our study was to determine the genetic influence on blood pressure in spontaneously hypertensive rats (SHR), and normotensive Wistar-Kyoto (WKY) rats using genetic crosses. Blood pressure was measured by tail sphygmomanometry from 8 to 20 weeks of age. Blood pressure was significantly higher from 12 to 20 weeks in the male offspring derived from WKY mothers x SHR fathers as compared with male offspring derived from SHR mothers X WKY fathers (180 +/- 4 versus 160 +/- 5 mm Hg, p less than 0.01). There was no significant difference between the blood pressure of the F1 females, further supporting Y chromosome linkage and not parental imprinting. The blood pressure data from F2 males derived from reciprocal crosses of parental strains were consistent with the presence of a Y-linked locus, but not with an X-linked locus controlling blood pressure. The data strongly suggest that hypertension in the SHR has two primary components of equal magnitude, one consisting of a small number of autosomal loci with a second Y-linked component.
D L Ely, and
M E Turner
October 1986,
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D L Ely, and
M E Turner
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D L Ely, and
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D L Ely, and
M E Turner
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
D L Ely, and
M E Turner
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Hypertension (Dallas, Tex. : 1979),
D L Ely, and
M E Turner
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D L Ely, and
M E Turner
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Hypertension (Dallas, Tex. : 1979),
D L Ely, and
M E Turner
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Hypertension (Dallas, Tex. : 1979),
D L Ely, and
M E Turner
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The American journal of physiology,
D L Ely, and
M E Turner
October 1991,
Hypertension (Dallas, Tex. : 1979),
