-transparent.png){kind=logo}
Vitamin E deficiency is a common consequence of chronic cholestatic liver disorders. Inasmuch as vitamin E content of cellular membranes alters membrane properties such as fluidity and molecular order, we postulated that vitamin E status could affect hepatocyte transport processes dependent on membrane integrity. Hepatocytes were isolated from rats maintained on diets containing deficient, sufficient, or excess vitamin E. Cell viability and oxygen consumption were maintained in all groups of hepatocytes. Hepatocyte uptake of taurocholic acid and ouabain and Na+,K(+)-ATPase activity estimated by rubidium-86 influx did not differ with vitamin E status. Vitamin-E-deficient hepatocytes had increased generation of lipid peroxide products. We conclude that deficient or excess vitamin E status had little effect on selected transport processes in normal hepatocytes.
R J Sokol, and
M W Devereaux, and
R A Khandwala, and
M R Narkewicz, and
N J Sondheimer
January 1994,
Life sciences,
R J Sokol, and
M W Devereaux, and
R A Khandwala, and
M R Narkewicz, and
N J Sondheimer
June 1988,
Biochemical pharmacology,
R J Sokol, and
M W Devereaux, and
R A Khandwala, and
M R Narkewicz, and
N J Sondheimer
September 1982,
The Journal of biological chemistry,
R J Sokol, and
M W Devereaux, and
R A Khandwala, and
M R Narkewicz, and
N J Sondheimer
April 1989,
Molecular and cellular endocrinology,
R J Sokol, and
M W Devereaux, and
R A Khandwala, and
M R Narkewicz, and
N J Sondheimer
August 1978,
Diabetologia,
R J Sokol, and
M W Devereaux, and
R A Khandwala, and
M R Narkewicz, and
N J Sondheimer
December 1977,
Molecular and cellular endocrinology,
R J Sokol, and
M W Devereaux, and
R A Khandwala, and
M R Narkewicz, and
N J Sondheimer
February 1978,
Endocrinology,
R J Sokol, and
M W Devereaux, and
R A Khandwala, and
M R Narkewicz, and
N J Sondheimer
February 2002,
Toxicology letters,
R J Sokol, and
M W Devereaux, and
R A Khandwala, and
M R Narkewicz, and
N J Sondheimer
January 1987,
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao,
R J Sokol, and
M W Devereaux, and
R A Khandwala, and
M R Narkewicz, and
N J Sondheimer
September 1986,
Experientia,
