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The early changes of electrophoretic mobility (EPM) of murine T lymphocytes induced by structural analogues of amixine-dihydrochloryde 4,4'-bis-[2(diethylamino)ethoxy]diphenyl (compound 1) and dihydrochloryde 2-methoxycarbonil-4,4'-bis-[2(diethylamino)ethoxy]diphenyl (compound 2) were studied by electrophoresis technique. During the interval 0-2 hours all compounds increased the absolute values of EPM in comparison with control. These changes were of the same kind--distinctions were quantitative. Amixine and compound 1 during the interval 2-4 hours additionally increased the EPM. The compound 2, on the contrary, decreased the EPM. It was shown that the opposite effects of the aforementioned compounds were caused by the fact that amixine and compound 1 induce, and compound 2 does not induce IFN production in T lymphocytes in vitro. The results of our experiments are important for understanding of the mechanisms of immunomodulating effect of amixine and its structural analogues.
O V Dolga, and
N Kh Pogoriela, and
O S Bohorad-Kobel's'ka, and
N M Zholobak, and
S O Zanoza, and
S A Liakhov, and
I S Mahura
January 2011,
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O V Dolga, and
N Kh Pogoriela, and
O S Bohorad-Kobel's'ka, and
N M Zholobak, and
S O Zanoza, and
S A Liakhov, and
I S Mahura
January 2009,
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994),
O V Dolga, and
N Kh Pogoriela, and
O S Bohorad-Kobel's'ka, and
N M Zholobak, and
S O Zanoza, and
S A Liakhov, and
I S Mahura
January 1986,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
O V Dolga, and
N Kh Pogoriela, and
O S Bohorad-Kobel's'ka, and
N M Zholobak, and
S O Zanoza, and
S A Liakhov, and
I S Mahura
February 1978,
Lancet (London, England),
O V Dolga, and
N Kh Pogoriela, and
O S Bohorad-Kobel's'ka, and
N M Zholobak, and
S O Zanoza, and
S A Liakhov, and
I S Mahura
January 1991,
Doklady Akademii nauk SSSR,
O V Dolga, and
N Kh Pogoriela, and
O S Bohorad-Kobel's'ka, and
N M Zholobak, and
S O Zanoza, and
S A Liakhov, and
I S Mahura
December 1987,
Gematologiia i transfuziologiia,
O V Dolga, and
N Kh Pogoriela, and
O S Bohorad-Kobel's'ka, and
N M Zholobak, and
S O Zanoza, and
S A Liakhov, and
I S Mahura
January 1974,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
O V Dolga, and
N Kh Pogoriela, and
O S Bohorad-Kobel's'ka, and
N M Zholobak, and
S O Zanoza, and
S A Liakhov, and
I S Mahura
July 1976,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
O V Dolga, and
N Kh Pogoriela, and
O S Bohorad-Kobel's'ka, and
N M Zholobak, and
S O Zanoza, and
S A Liakhov, and
I S Mahura
August 1985,
Biochimica et biophysica acta,
O V Dolga, and
N Kh Pogoriela, and
O S Bohorad-Kobel's'ka, and
N M Zholobak, and
S O Zanoza, and
S A Liakhov, and
I S Mahura
October 1977,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
