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In the present investigation, the involvement of PMNLs and oxygen free radicals was explored in rats with postischemic perfusion disturbances of the brain. Reversible forebrain ischemia was induced by bilateral clamping of both carotid arteries in combination with hemorrhagic hypotension. This procedure resulted in a reproducible DPH 1 hr after start of recirculation. Neutropenia was induced by sheep ANS. One group received ANS before and a second group immediately after termination of ischemia. Two additional groups received SOD before or immediately after ischemia. Regional postischemic CBF was determined by [14C]iodoantipyrine autoradiography. It was found that CBF significantly improved in cortical structures of animals treated with ANS before ischemia. Treatment with ANS at the end of ischemia had no effect on the postischemic CBF depression. Neither was injection of SOD effective to influence DPH, irrespective whether given before or after ischemia. It is concluded that PMNLs play a role in the development of DPH of the brain, whereas free radical mechanisms seem to be less relevant.
L Schürer, and
B Grögaard, and
B Gerdin, and
K E Arfors
January 1986,
Free radical research communications,
L Schürer, and
B Grögaard, and
B Gerdin, and
K E Arfors
January 1993,
Experientia,
L Schürer, and
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K E Arfors
January 1994,
Ophthalmic research,
L Schürer, and
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K E Arfors
June 1991,
The Annals of thoracic surgery,
L Schürer, and
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July 1976,
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L Schürer, and
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K E Arfors
December 1996,
Biochemical pharmacology,
L Schürer, and
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K E Arfors
May 1992,
Journal of hepatology,
L Schürer, and
B Grögaard, and
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K E Arfors
January 1999,
Journal of anesthesia,
L Schürer, and
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K E Arfors
January 1982,
Gerontology,
L Schürer, and
B Grögaard, and
B Gerdin, and
K E Arfors
July 1978,
Journal of neurochemistry,
