BIOMAT Database Logo BIOMAT Database Logo

Early life arsenic exposure and acute and long-term responses to influenza A infection in mice. 2013

Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
Division of Clinical Sciences, Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia.

BACKGROUND Arsenic is a significant global environmental health problem. Exposure to arsenic in early life has been shown to increase the rate of respiratory infections during infancy, reduce childhood lung function, and increase the rates of bronchiectasis in early adulthood. OBJECTIVE We aimed to determine if early life exposure to arsenic exacerbates the response to early life influenza infection in mice. METHODS C57BL/6 mice were exposed to arsenic in utero and throughout postnatal life. At 1 week of age, a subgroup of mice were infected with influenza A. We then assessed the acute and long-term effects of arsenic exposure on viral clearance, inflammation, lung structure, and lung function. RESULTS Early life arsenic exposure reduced the clearance of and exacerbated the inflammatory response to influenza A, and resulted in acute and long-term changes in lung mechanics and airway structure. CONCLUSIONS Increased susceptibility to respiratory infections combined with exaggerated inflammatory responses throughout early life may contribute to the development of bronchiectasis in arsenic-exposed populations.

UI MeSH Term Description Entries
D007251 Influenza, Human An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia. Grippe,Human Flu,Human Influenza,Influenza in Humans,Influenza,Flu, Human,Human Influenzas,Influenza in Human,Influenzas,Influenzas, Human
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D012141 Respiratory Tract Infections Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases. Respiratory System Infections,Upper Respiratory Tract Infection,Upper Respiratory Tract Infections,Infections, Respiratory,Infections, Respiratory Tract,Infections, Upper Respiratory,Infections, Upper Respiratory Tract,Respiratory Infections,Upper Respiratory Infections,Infection, Respiratory System,Infection, Respiratory Tract,Respiratory Infection, Upper,Respiratory System Infection,Respiratory Tract Infection
D001987 Bronchiectasis Persistent abnormal dilatation of the bronchi. Cylindrical Bronchiectasis,Cystic Bronchiectasis,Saccular Bronchiectasis,Varicose Bronchiectasis,Bronchiectases,Bronchiectasis, Cylindrical,Bronchiectasis, Cystic,Bronchiectasis, Saccular,Bronchiectasis, Varicose,Cylindrical Bronchiectases,Cystic Bronchiectases,Saccular Bronchiectases,Varicose Bronchiectases
D004781 Environmental Exposure The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals. Exposure, Environmental,Environmental Exposures,Exposures, Environmental
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
In utero and early life arsenic exposure in relation to long-term health and disease.
October 2013, Toxicology and applied pharmacology,
Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
In utero arsenic exposure in mice and early life susceptibility to cancer.
October 2015, Regulatory toxicology and pharmacology : RTP,
Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
Long-Term Effects of Early-Life Antibiotic Exposure on Resistance to Subsequent Bacterial Infection.
December 2019, mBio,
Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
Exposure to Early Life Pain: Long Term Consequences and Contributing Mechanisms.
February 2016, Current opinion in behavioral sciences,
Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
Health effects of early life exposure to arsenic.
February 2008, Basic & clinical pharmacology & toxicology,
Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
Early life opioid exposure and potential long-term effects.
February 2019, Neurobiology of stress,
Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
Early-life exposure to Ivermectin alters long-term growth and disease susceptibility.
January 2021, PloS one,
Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
Long term immune responses to pandemic influenza A/H1N1 infection in solid organ transplant recipients.
January 2011, PloS one,
Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
Geogenic PM₁₀ exposure exacerbates responses to influenza infection.
November 2015, The Science of the total environment,
Kathryn A Ramsey, and Rachel E Foong, and Peter D Sly, and Alexander N Larcombe, and Graeme R Zosky
Long-term exposure to arsenic affects head kidney and impairs humoral immune responses of Clarias batrachus.
February 2007, Aquatic toxicology (Amsterdam, Netherlands),
Copied contents to your clipboard!