-transparent.png){kind=logo}
BACKGROUND Chronic bronchitis in COPD has been associated with an increased exacerbation rate, more hospitalizations, and an accelerated decline in lung function. The clinical characteristics of patients with advanced emphysema and chronic bronchitis have not been well described. METHODS Patients randomized to medical therapy in the National Emphysema Treatment Trial were grouped based on their reports of cough and phlegm on the St. George's Respiratory Questionnaire(SGRQ) at baseline: chronic bronchitis(CB+) and no chronic bronchitis(CB-). The patients were similarly categorized into severe chronic bronchitis(SCB+) or no severe chronic bronchitis (SCB-) based on the above definition plus report of chest trouble. Kaplan-Meier survival analysis was used to determine the relationships between chronic bronchitis and severe chronic bronchitis and survival and time to hospitalization. Lung function and SGRQ scores over time were compared between groups. RESULTS The CB+(N = 234; 38%) and CB- groups(N = 376; 62%) had similar survival (median 60.8 versus 65.7 months, p = 0.19) and time to hospitalization (median 26.9 versus 24.9 months, p = 0.84). The SCB+ group(N = 74; 12%) had worse survival (median 47.7 versus 65.7 months, p = 0.02) and shorter time to hospitalization (median 18.5 versus 26.7 months, p = 0.02) than the SCB- group (N = 536; 88%). Mortality and hospitalization rates were not increased when chest trouble was analyzed by itself. The CB+ and CB-groups had similar lung function and SGRQ scores over time. The SCB+ and SCB-groups had similar lung function over time, but the SCB+ group had significantly worse SGRQ scores. CONCLUSIONS Severe chronic bronchitis is associated with worse survival, shorter time to hospitalization, and worse health-related quality of life.
Victor Kim, and
Alice L Sternberg, and
George Washko, and
Barry J Make, and
Meilan K Han, and
Fernando Martinez, and
Gerard J Criner, and
March 1968,
The New England journal of medicine,
Victor Kim, and
Alice L Sternberg, and
George Washko, and
Barry J Make, and
Meilan K Han, and
Fernando Martinez, and
Gerard J Criner, and
March 1968,
The New England journal of medicine,
Victor Kim, and
Alice L Sternberg, and
George Washko, and
Barry J Make, and
Meilan K Han, and
Fernando Martinez, and
Gerard J Criner, and
September 1959,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
Victor Kim, and
Alice L Sternberg, and
George Washko, and
Barry J Make, and
Meilan K Han, and
Fernando Martinez, and
Gerard J Criner, and
March 1964,
Modern treatment,
Victor Kim, and
Alice L Sternberg, and
George Washko, and
Barry J Make, and
Meilan K Han, and
Fernando Martinez, and
Gerard J Criner, and
November 1968,
Maryland state medical journal,
Victor Kim, and
Alice L Sternberg, and
George Washko, and
Barry J Make, and
Meilan K Han, and
Fernando Martinez, and
Gerard J Criner, and
February 1935,
British medical journal,
Victor Kim, and
Alice L Sternberg, and
George Washko, and
Barry J Make, and
Meilan K Han, and
Fernando Martinez, and
Gerard J Criner, and
May 1978,
British medical journal,
Victor Kim, and
Alice L Sternberg, and
George Washko, and
Barry J Make, and
Meilan K Han, and
Fernando Martinez, and
Gerard J Criner, and
May 1973,
The Medical clinics of North America,
Victor Kim, and
Alice L Sternberg, and
George Washko, and
Barry J Make, and
Meilan K Han, and
Fernando Martinez, and
Gerard J Criner, and
January 1961,
Bulletin. Buffalo (N.Y.). Millard Fillmore Hospital,
Victor Kim, and
Alice L Sternberg, and
George Washko, and
Barry J Make, and
Meilan K Han, and
Fernando Martinez, and
Gerard J Criner, and
January 1964,
Bulletins et memoires de la Societe medicale des hopitaux de Paris,
