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The zoonotic, fish-borne liver flukes Clonorchis sinensis, Opisthorchis felineus and Opisthorchis viverrini. 2013

Trevor N Petney, and Ross H Andrews, and Weerachai Saijuntha, and Alexandra Wenz-Mücke, and Paiboon Sithithaworn
Institute of Zoology, Department of Ecology and Parasitology, Karlsruhe Institute of Technology, Kornblumenstrasse 13, Karlsruhe 76131, Germany.

Clonorchis sinensis, Opisthorchis felineus and Opisthorchis viverrini are the three most important liver flukes involved in human health, infecting more than 45 million people worldwide. Both C. sinensis and O. viverrini, and possibly O. felineus, can induce human cholangiocarcinoma as well as inducing other hepatobiliary pathology. Although the life cycles of all three species are similar, only that of O. felineus in Europe remains predominantly zoonotic, while O. felineus in Asia and C. sinensis have a stronger mixture of zoonotic and anthroponotic components in their life cycles. Opisthorchis viverrini from the Mekong area of southeastern Asia is predominantly anthroponotic. Here we discuss the comparative epidemiology of these three taxa comparing in detail the use of first, second and final animal hosts, and consider the potential role of humans in spreading these pathogens. In addition we discuss the genetic structure of all three species in relation to potentially cryptic species complexes.

UI MeSH Term Description Entries
D009889 Opisthorchiasis Infection with flukes of the genus Opisthorchis. Opisthorchis Infection,Opisthorchis felineus Infection,Opisthorchis viverrini Infection,Infection, Opisthorchis,Infection, Opisthorchis felineus,Infection, Opisthorchis viverrini,Infections, Opisthorchis,Infections, Opisthorchis felineus,Infections, Opisthorchis viverrini,Opisthorchiases,Opisthorchis Infections,Opisthorchis felineus Infections,Opisthorchis viverrini Infections
D009891 Opisthorchis A genus of trematode liver flukes of the family Opisthorchidae. It consists of the following species: O. felineus, O. noverca (Amphimerus noverca), and O. viverrini. The intermediate hosts are snails, fish, and AMPHIBIANS. Opisthorchis felineus,Opisthorchis viverrini,Opisthorchi,Opisthorchis viverrinus,viverrini, Opisthorchis
D003003 Clonorchiasis Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed) Clonorchis Infection,Clonorchis sinensis Infection,Opisthorchis sinensis Infection,Clonorchiases,Clonorchis Infections,Clonorchis sinensis Infections,Infection, Clonorchis,Infection, Clonorchis sinensis,Infection, Opisthorchis sinensis,Opisthorchis sinensis Infections
D003004 Clonorchis sinensis A species of trematode flukes of the family Opisthorchidae. Many authorities consider this genus belonging to Opisthorchis. It is common in China and other Asiatic countries. Snails and fish are the intermediate hosts. Opisthorchis sinensis,Clonorchis sinenses,Opisthorchis sinenses,sinenses, Opisthorchis,sinensis, Clonorchis
D005399 Fishes A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015047 Zoonoses Diseases of non-human animals that may be transmitted to HUMANS or may be transmitted from humans to non-human animals. Zoonotic Spillover,Zoonotic Diseases,Zoonotic Infections,Zoonotic Infectious Diseases,Disease, Zoonotic,Disease, Zoonotic Infectious,Diseases, Zoonotic,Diseases, Zoonotic Infectious,Infection, Zoonotic,Infections, Zoonotic,Infectious Disease, Zoonotic,Infectious Diseases, Zoonotic,Spillovers, Zoonotic,Zoonotic Disease,Zoonotic Infection,Zoonotic Infectious Disease,Zoonotic Spillovers

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