BIOMAT Database Logo BIOMAT Database Logo

Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1. 1990

Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts.

The negative regulatory element of human immunodeficiency virus type 1 is a 260-nucleotide-long sequence that decreases the rate of RNA transcription initiation specified by the long terminal repeat. This region has the potential to bind several cellular transcription factors. Here it is shown that sequences which recognize the NFAT-1 and USF cellular transcription factors contribute to this negative regulatory effect. The sequences within the negative regulatory element which resemble the AP-1 site and the URS do not negatively regulate human immunodeficiency virus long terminal repeat transcription initiation.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D011401 Promoter Regions, Genetic DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes. rRNA Promoter,Early Promoters, Genetic,Late Promoters, Genetic,Middle Promoters, Genetic,Promoter Regions,Promoter, Genetic,Promotor Regions,Promotor, Genetic,Pseudopromoter, Genetic,Early Promoter, Genetic,Genetic Late Promoter,Genetic Middle Promoters,Genetic Promoter,Genetic Promoter Region,Genetic Promoter Regions,Genetic Promoters,Genetic Promotor,Genetic Promotors,Genetic Pseudopromoter,Genetic Pseudopromoters,Late Promoter, Genetic,Middle Promoter, Genetic,Promoter Region,Promoter Region, Genetic,Promoter, Genetic Early,Promoter, rRNA,Promoters, Genetic,Promoters, Genetic Middle,Promoters, rRNA,Promotor Region,Promotors, Genetic,Pseudopromoters, Genetic,Region, Genetic Promoter,Region, Promoter,Region, Promotor,Regions, Genetic Promoter,Regions, Promoter,Regions, Promotor,rRNA Promoters
D011533 Proviruses Duplex DNA sequences in eukaryotic chromosomes, corresponding to the genome of a virus, that are transmitted from one cell generation to the next without causing lysis of the host. Proviruses are often associated with neoplastic cell transformation and are key features of retrovirus biology. Provirus
D012091 Repetitive Sequences, Nucleic Acid Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES). DNA Repetitious Region,Direct Repeat,Genes, Selfish,Nucleic Acid Repetitive Sequences,Repetitive Region,Selfish DNA,Selfish Genes,DNA, Selfish,Repetitious Region, DNA,Repetitive Sequence,DNA Repetitious Regions,DNAs, Selfish,Direct Repeats,Gene, Selfish,Repeat, Direct,Repeats, Direct,Repetitious Regions, DNA,Repetitive Regions,Repetitive Sequences,Selfish DNAs,Selfish Gene
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002467 Cell Nucleus Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) Cell Nuclei,Nuclei, Cell,Nucleus, Cell
D002872 Chromosome Deletion Actual loss of portion of a chromosome. Monosomy, Partial,Partial Monosomy,Deletion, Chromosome,Deletions, Chromosome,Monosomies, Partial,Partial Monosomies
D005814 Genes, Viral The functional hereditary units of VIRUSES. Viral Genes,Gene, Viral,Viral Gene

Related Publications

Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences.
August 1997, Virology,
Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
cis-acting sequences involved in human immunodeficiency virus type 1 RNA packaging.
October 1995, Journal of virology,
Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
Identification of a novel cell-type and context specific enhancer within the negative regulatory element of the human immunodeficiency virus type 1 long terminal repeat.
January 1994, Archives of virology,
Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
Let It Go: HIV-1 cis-Acting Repressive Sequences.
July 2021, Journal of virology,
Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
Identification of transcriptional suppressor proteins that bind to the negative regulatory element of the human immunodeficiency virus type 1.
November 1991, Nucleic acids research,
Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
Packaging of human immunodeficiency virus type 1 RNA requires cis-acting sequences outside the 5' leader region.
July 1993, Journal of virology,
Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
cis-acting negative regulatory element of prolactin gene.
March 1990, The Journal of biological chemistry,
Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
A novel cis-acting element that controls transcription of human immunodeficiency virus type 1 DNA, depending on cell type.
November 1991, Journal of virology,
Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
Analysis in human immunodeficiency virus type 1 vectors of cis-acting sequences that affect gene transfer into human lymphocytes.
June 1994, Journal of virology,
Y C Lu, and N Touzjian, and M Stenzel, and T Dorfman, and J G Sodroski, and W A Haseltine
Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus.
April 1988, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!