Biomaterial Database

[Development of Tc-99m labeled activated carbon microspheres and clinical application]. 1990

T Saeki, and Y Karaki, and M Maeda, and T Honda, and M Fujimaki

2nd Department of Surgery, Toyama Medical and Pharmaceutical University, Japan.

We have developed Tc-99m labeled activated carbon microspheres (99mTc-CH44) for use in mammary lymphoscintigraphy and detailed analysis of mammary lymph flow. 99mTc-CH44 was prepared according to the EDTA complex method. The labeling rate immediately after preparation was 97.7 +/- 2.6% at 37 degrees C and was 94.9 +/- 2.6% after 24-hour continuous shaking. The release of 99mTcO4- from 99mTc-CH44 was determined in vitro, using a simulation model. In this assay, the 99mTcO4- release rate in one hour was 6.6% and that in 6 hours was 38%. When 2ml (2mCi, 74MBq) of 99mTc-CH44 was injected into the mammary glands of 12 patients with breast tumors, the axillary, subclavian and parasternal lymph nodes of 10 patients were visualized 60 minutes later. In analysis of lymph flow in 25 rats using 99mTc-CH44 the lymph flow from the foot pad through the popliteal to the intraperitoneal lymph nodes was known to have only one route when examined by gross finding and histology. However, the examination using RI-technique indicated two routes. The examination in 9 patients with breast cancer indicated that the use of 99mTc-CH44 allowed detailed analysis of lymph flow. These results suggest that 99mTc-CH44 is useful for the preoperative mammary lymphoscintigraphy and detailed analysis of mammary lymph flow.

UI	MeSH Term	Description	Entries
D008196	Lymph	The interstitial fluid that is in the LYMPHATIC SYSTEM.	Lymphs
D008198	Lymph Nodes	They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.	Lymph Node,Node, Lymph,Nodes, Lymph
D008297	Male		Males
D008863	Microspheres	Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.	Latex Beads,Latex Particles,Latex Spheres,Microbeads,Bead, Latex,Beads, Latex,Latex Bead,Latex Particle,Latex Sphere,Microbead,Microsphere,Particle, Latex,Particles, Latex,Sphere, Latex,Spheres, Latex
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011877	Radionuclide Imaging	The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.	Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D001943	Breast Neoplasms	Tumors or cancer of the human BREAST.	Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002244	Carbon	A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.	Carbon-12,Vitreous Carbon,Carbon 12,Carbon, Vitreous
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults