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The detoxifying function of the liver was studied in experiments on male rats with acute obstructive and strangulation ileus. Irrespective of its type, acute ileus was attended by marked diminution of hepatic detoxifying function the underlying factor of which was inhibited activity of the main microsomal enzymes and reduced content of cytochromes p50 and b5 in the liver. Intoxication of the organism and hypoxia developing in the liver were among the causes of inhibited activity of the microsomal enzymes. The detoxifying function is not normalized in the early periods after relief of acute intestinal obstruction.
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