BIOMAT Database Logo BIOMAT Database Logo

An immunodominant HLA-A*1101-restricted CD8+ T-cell response targeting hepatitis B surface antigen in chronic hepatitis B patients. 2013

Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
Department of Immunology, Third Military Medical University & Institute of Immunology, PLA, Chongqing 400038, PR China.

Hepatitis B virus (HBV) infection is a worldwide public health problem. HBV-specific CD8(+) CTLs are vital for viral clearance. Identification of immunodominant CTL epitopes from HBV-associated antigens is necessary for therapeutic vaccine development. We showed that the HLA-A*1101 allele is one of the most common alleles in both healthy individuals and chronic hepatitis B (CHB) patients in the Chongqing area, China. However, less than 10% of epitopes of HBV-associated antigens have been identified in an HLA-A*1101 context. Here, we describe an immunodominant CD8(+) T-cell response targeting a hepatitis B surface antigen determinant (HBs(295-304)) restricted by HLA-A*1101 in both healthy individuals and CHB patients. Moreover, HBs(295-304) is more immunogenic for CTL induction than a known naturally HLA-A*1101-processed epitope from hepatitis B core antigen (HBc(88-96)). Therefore, the newly identified epitope, HBs(295-304), will benefit the development of immunotherapeutic approaches for HBV infection.

UI MeSH Term Description Entries
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D006512 Hepatitis B Core Antigens The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion. HBcAg,Hepatitis B Core Antigen
D006514 Hepatitis B Surface Antigens Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen. Australia Antigen,HBsAg,Hepatitis B Surface Antigen,Antigen, Australia
D006515 Hepatitis B virus The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum. Dane Particle,Hepatitis Virus, Homologous Serum,B virus, Hepatitis,Hepatitis B viruses,Particle, Dane,viruses, Hepatitis B
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016056 Immunodominant Epitopes Subunits of the antigenic determinant that are most easily recognized by the immune system and thus most influence the specificity of the induced antibody. Antigenic Determinants, Immunodominant,Antigens, Immunodominant,Epitopes, Immunodominant,Immunodominant Determinant,Immunodominant Domain,Immunodominant Epitope,Immunodominant Region,Immunodominant Site,Immunodominant Determinants,Immunodominant Domains,Immunodominant Regions,Immunodominant Sites,Determinant, Immunodominant,Determinants, Immunodominant,Determinants, Immunodominant Antigenic,Domain, Immunodominant,Domains, Immunodominant,Epitope, Immunodominant,Immunodominant Antigenic Determinants,Immunodominant Antigens,Region, Immunodominant,Regions, Immunodominant,Site, Immunodominant,Sites, Immunodominant
D059870 HLA-A11 Antigen A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*11 allele family. HLA A11,HLA Class I Histocompatibility Antigen, A-11 alpha Chain,HLA-A11,HLA Class I Histocompatibility Antigen, A 11 alpha Chain
D018414 CD8-Positive T-Lymphocytes A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes. Suppressor T-Lymphocytes, CD8-Positive,T8 Cells,T8 Lymphocytes,CD8-Positive Lymphocytes,Suppressor T-Cells, CD8-Positive,CD8 Positive Lymphocytes,CD8 Positive T Lymphocytes,CD8-Positive Lymphocyte,CD8-Positive Suppressor T-Cell,CD8-Positive Suppressor T-Cells,CD8-Positive Suppressor T-Lymphocyte,CD8-Positive Suppressor T-Lymphocytes,CD8-Positive T-Lymphocyte,Cell, T8,Cells, T8,Lymphocyte, CD8-Positive,Lymphocyte, T8,Lymphocytes, CD8-Positive,Lymphocytes, T8,Suppressor T Cells, CD8 Positive,Suppressor T Lymphocytes, CD8 Positive,Suppressor T-Cell, CD8-Positive,Suppressor T-Lymphocyte, CD8-Positive,T-Cell, CD8-Positive Suppressor,T-Cells, CD8-Positive Suppressor,T-Lymphocyte, CD8-Positive,T-Lymphocyte, CD8-Positive Suppressor,T-Lymphocytes, CD8-Positive,T-Lymphocytes, CD8-Positive Suppressor,T8 Cell,T8 Lymphocyte
D019694 Hepatitis B, Chronic INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Chronic Hepatitis B,Chronic Hepatitis B Virus Infection,Hepatitis B Virus Infection, Chronic

Related Publications

Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.
January 2012, PLoS pathogens,
Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
Presentation of an immunodominant T-cell epitope of hepatitis B surface antigen by the HLA-DPw4 molecule.
February 1989, Journal of virology,
Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
Silencing an immunodominant epitope of hepatitis B surface antigen reveals an alternative repertoire of CD8 T cell epitopes of this viral antigen.
December 2009, Vaccine,
Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B.
September 2007, PLoS pathogens,
Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
The immunodominant, Ld-restricted T cell response to hepatitis B surface antigen (HBsAg) efficiently suppresses T cell priming to multiple Dd-, Kd-, and Kb-restricted HBsAg epitopes.
June 2002, Journal of immunology (Baltimore, Md. : 1950),
Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
In vivo hierarchy of immunodominant and subdominant HLA-A*0201-restricted T-cell epitopes of HBx antigen of hepatitis B virus.
April 2005, Microbes and infection,
Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
Preliminary exploration of HLA-A 1101-restricted human cytomegalovirus glycoprotein B-specific CD8⁺ T cells in allogeneic stem-cell transplant recipients.
August 2014, Virus research,
Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.
September 2010, Virology,
Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
Mutation "hot spot" in HLA class I-restricted T cell epitope on hepatitis B surface antigen in chronic carriers and hepatocellular carcinoma.
September 1999, Biochemical and biophysical research communications,
Xiaoling Chen, and Wenbo Wang, and Shufeng Wang, and Gang Meng, and Mengjun Zhang, and Bing Ni, and Yuzhang Wu, and Li Wang
HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection.
May 1993, Journal of immunology (Baltimore, Md. : 1950),
Copied contents to your clipboard!