Identification of volatiles by headspace gas chromatography with simultaneous flame ionization and mass spectrometric detection. 2013

Nicholas B Tiscione, and Dustin Tate Yeatman, and Xiaoqin Shan, and Joseph H Kahl
1 Palm Beach County Sheriff's Office, 3228 Gun Club Road, West Palm Beach, FL 33406, USA.

Volatiles are frequently abused as inhalants. The methods used for identification are generally nonspecific if analyzed concurrently with ethanol or require an additional analytical procedure that employs mass spectrometry. A previously published technique utilizing a capillary flow technology splitter to simultaneously quantitate and confirm ethyl alcohol by flame ionization and mass spectrometric detection after headspace sampling and gas chromatographic separation was evaluated for the detection of inhalants. Methanol, isopropanol, acetone, acetaldehyde, toluene, methyl ethyl ketone, isoamyl alcohol, isobutyl alcohol, n-butyl alcohol, 1,1-difluoroethane, 1,1,1-trifluoroethane, 1,1,1,2-tetrafluoroethane (Norflurane, HFC-134a), chloroethane, trichlorofluoromethane (Freon®-11), dichlorodifluoromethane (Freon®-12), dichlorofluoromethane (Freon®-21), chlorodifluoromethane (Freon®-22) and 1,2-dichlorotetrafluoroethane (Freon®-114) were validated for qualitative identification by this method. The validation for qualitative identification included evaluation of matrix effects, sensitivity, carryover, specificity, repeatability and ruggedness/robustness.

UI MeSH Term Description Entries
D008297 Male Males
D005260 Female Females
D005410 Flame Ionization Pyrolysis of organic compounds at the temperature of a hydrogen-air flame to produce ionic intermediates which can be collected and the resulting ion current measured by gas chromatography. Flame Ionizations,Ionization, Flame,Ionizations, Flame
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D013058 Mass Spectrometry An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers. Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass
D013287 Illicit Drugs Drugs that are manufactured, obtained, or sold illegally. They include prescription drugs obtained or sold without prescription and non-prescription drugs. Illicit drugs are widely distributed, tend to be grossly impure and may cause unexpected toxicity. Club Drug,Drugs, Illegal,Illegal Drug,Illegal Drugs,Illicit Drug,Recreational Drug,Recreational Drugs,Street Drug,Street Drugs,Club Drugs,Drug, Club,Drug, Illegal,Drug, Illicit,Drug, Recreational,Drug, Street,Drugs, Club,Drugs, Illicit,Drugs, Recreational,Drugs, Street
D014835 Volatilization A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation. Vaporization,Volatility
D015203 Reproducibility of Results The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results. Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D015813 Substance Abuse Detection Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection. Drug Abuse Testing,Illicit Drug Testing,Street Drug Testing,Substance Abuse Testing,Drug Abuse Detection,Drug Abuse Screening,Illicit Drug Detection,Street Drug Detection,Detection, Drug Abuse,Detection, Illicit Drug,Detection, Street Drug,Detection, Substance Abuse,Detections, Drug Abuse,Detections, Illicit Drug,Detections, Street Drug,Detections, Substance Abuse,Drug Abuse Detections,Drug Abuse Screenings,Drug Abuse Testings,Drug Testing, Illicit,Drug Testings, Illicit,Illicit Drug Detections,Illicit Drug Testings,Screening, Drug Abuse,Screenings, Drug Abuse,Street Drug Detections,Street Drug Testings,Substance Abuse Detections,Substance Abuse Testings,Testing, Drug Abuse,Testing, Illicit Drug,Testing, Street Drug,Testing, Substance Abuse,Testings, Drug Abuse,Testings, Illicit Drug,Testings, Street Drug,Testings, Substance Abuse

Related Publications

Nicholas B Tiscione, and Dustin Tate Yeatman, and Xiaoqin Shan, and Joseph H Kahl
March 2013, Journal of chromatography. A,
Nicholas B Tiscione, and Dustin Tate Yeatman, and Xiaoqin Shan, and Joseph H Kahl
August 2018, Journal of chromatography. A,
Nicholas B Tiscione, and Dustin Tate Yeatman, and Xiaoqin Shan, and Joseph H Kahl
August 2005, International journal of cosmetic science,
Nicholas B Tiscione, and Dustin Tate Yeatman, and Xiaoqin Shan, and Joseph H Kahl
July 2008, Journal of chromatography. A,
Nicholas B Tiscione, and Dustin Tate Yeatman, and Xiaoqin Shan, and Joseph H Kahl
January 2003, Journal of chromatography. A,
Nicholas B Tiscione, and Dustin Tate Yeatman, and Xiaoqin Shan, and Joseph H Kahl
January 2011, Journal of chromatography. A,
Nicholas B Tiscione, and Dustin Tate Yeatman, and Xiaoqin Shan, and Joseph H Kahl
January 1988, Journal - Association of Official Analytical Chemists,
Nicholas B Tiscione, and Dustin Tate Yeatman, and Xiaoqin Shan, and Joseph H Kahl
January 2011, Journal of AOAC International,
Nicholas B Tiscione, and Dustin Tate Yeatman, and Xiaoqin Shan, and Joseph H Kahl
June 2006, Journal of agricultural and food chemistry,
Copied contents to your clipboard!