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Non-small cell lung cancer (NSCLC) comprises 80% of all lung cancers and is characterized by multiple genetic alterations such as loss of heterozygosity (LOH) and microsatellite instability (MSI). The aim of the study was to analyze of molecular-genetic alterations in tumor and tissue surrounding the tumor to determine genetic features of different histological types of NSCLC and its possible associations with clinicopathological parameters of patients. A microsatellite analysis of chromosomal regions 12p23.3, 2q35, 3p14.2, 3p22.2, 3p26.3, 9p22.1, 17p13.3 was performed. The frequency of genetic alterations in NSCLC was 50% in average. LOH/MSI in the tumor surrounding tissue at 2 and 5 cm. from tumor was not detected. There were statistically significant associations between LOH and/or MSI and the tumor stage, its histological type and smoking status. The found genetic alterations can be used as molecular markers of squamous cell lung cancer in difficult diagnostic cases and appraised as prognostic markers.
A A Shikeeva, and
T V Kekeeva, and
L É Zavalishina, and
Iu Iu Andreeva, and
G A Frank
September 2015,
Journal of clinical pathology,
A A Shikeeva, and
T V Kekeeva, and
L É Zavalishina, and
Iu Iu Andreeva, and
G A Frank
May 1998,
British journal of cancer,
A A Shikeeva, and
T V Kekeeva, and
L É Zavalishina, and
Iu Iu Andreeva, and
G A Frank
August 2000,
Cancer research,
A A Shikeeva, and
T V Kekeeva, and
L É Zavalishina, and
Iu Iu Andreeva, and
G A Frank
October 2008,
ONS connect,
A A Shikeeva, and
T V Kekeeva, and
L É Zavalishina, and
Iu Iu Andreeva, and
G A Frank
April 2014,
Medicine and science in sports and exercise,
A A Shikeeva, and
T V Kekeeva, and
L É Zavalishina, and
Iu Iu Andreeva, and
G A Frank
June 1986,
The American journal of medicine,
A A Shikeeva, and
T V Kekeeva, and
L É Zavalishina, and
Iu Iu Andreeva, and
G A Frank
September 2003,
Clinical lung cancer,
A A Shikeeva, and
T V Kekeeva, and
L É Zavalishina, and
Iu Iu Andreeva, and
G A Frank
January 2018,
Journal of oncology practice,
A A Shikeeva, and
T V Kekeeva, and
L É Zavalishina, and
Iu Iu Andreeva, and
G A Frank
April 1993,
Gan to kagaku ryoho. Cancer & chemotherapy,
A A Shikeeva, and
T V Kekeeva, and
L É Zavalishina, and
Iu Iu Andreeva, and
G A Frank
January 2012,
Pneumonologia i alergologia polska,
