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Peroxidases are involved in a number of cytotoxic reactions. Murine thioglycollate-induced peritoneal macrophages were exposed to either lactoperoxidase or microperoxidase in vitro. At a concentration of 17.7 microM, both of these enzymes induced between 100 and 200 units of tumor necrosis factor (TNF) per 0.1 ml. Furthermore, these substances were able to stimulate macrophages to kill 3T12 target cells in a dose dependent manner at concentrations of 0.177 microM to 17.7 microM. Per cent cytotoxicity varied from 20% up to 75% at the higher concentrations. It was concluded that these enzymes can induce macrophages to secrete TNF and become activated to the cytotoxic state.
D L Lefkowitz, and
T C Hsieh, and
K Mills, and
A Castro
October 1989,
Cellular immunology,
D L Lefkowitz, and
T C Hsieh, and
K Mills, and
A Castro
November 1989,
Nihon saikingaku zasshi. Japanese journal of bacteriology,
D L Lefkowitz, and
T C Hsieh, and
K Mills, and
A Castro
January 1996,
Immunobiology,
D L Lefkowitz, and
T C Hsieh, and
K Mills, and
A Castro
January 1990,
Microbiology and immunology,
D L Lefkowitz, and
T C Hsieh, and
K Mills, and
A Castro
November 1992,
The Journal of clinical investigation,
D L Lefkowitz, and
T C Hsieh, and
K Mills, and
A Castro
January 2002,
The Journal of biological chemistry,
D L Lefkowitz, and
T C Hsieh, and
K Mills, and
A Castro
September 1990,
Nihon saikingaku zasshi. Japanese journal of bacteriology,
D L Lefkowitz, and
T C Hsieh, and
K Mills, and
A Castro
August 1992,
Acta virologica,
D L Lefkowitz, and
T C Hsieh, and
K Mills, and
A Castro
October 2000,
FEBS letters,
D L Lefkowitz, and
T C Hsieh, and
K Mills, and
A Castro
January 1993,
Toxicology and applied pharmacology,
