Biomaterial Database

[Quantitative measurement of IAP (immunosuppressive acidic protein) in patients with retinoblastoma]. 1990

R Takahashi, and K Yamaguchi, and M Tamai

Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.

Immunosuppressive acidic protein (IAP) is a useful tumor marker for evaluating clinical course, therapeutic effectiveness, and prognosis of patients with various malignant tumors. In this report, we examined the serum IAP levels in 20 patients with retinoblastomas. In 6 cases, both preoperative and postoperative IAP values were examined, and in 14 cases the levels of this protein were postoperatively followed. Although 2 of 6 cases had higher levels of IAP than 500 micrograms/ml preoperatively, they had decreased within the normal range (less than 500 micrograms/ml) postoperatively. The mean IAP levels at 1-2 weeks before, 1-2 weeks after and 1 month after surgery were 422 +/- 225.1 micrograms/ml, 221 +/- 62.6 micrograms/ml, and 297 +/- 89.8 micrograms/ml, respectively, that means IAP decreased after enucleation. In 14 cases in which this protein was examined only postoperatively the value was 314.5 +/- 91.6 micrograms/ml. In one case with a level of 856 micrograms/ml of IAP before enucleation, pathological examination revealed invasion of retinoblastoma cells to the optic nerve and orbital fat. The high level of IAP might be related to the extraocular invasion. Since the level of serum IAP decreased after enucleation, these results suggested that immunological activities might change, even though tumor cells grew within the blood retinal barrier.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D008297	Male		Males
D009363	Neoplasm Proteins	Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.	Proteins, Neoplasm
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005134	Eye Neoplasms	Tumors or cancer of the EYE.	Cancer of Eye,Eye Cancer,Cancer of the Eye,Neoplasms, Eye,Cancer, Eye,Cancers, Eye,Eye Cancers,Eye Neoplasm,Neoplasm, Eye
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012175	Retinoblastoma	A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)	Glioblastoma, Retinal,Glioma, Retinal,Neuroblastoma, Retinal,Eye Cancer, Retinoblastoma,Familial Retinoblastoma,Hereditary Retinoblastoma,Sporadic Retinoblastoma,Cancer, Retinoblastoma Eye,Cancers, Retinoblastoma Eye,Eye Cancers, Retinoblastoma,Familial Retinoblastomas,Glioblastomas, Retinal,Gliomas, Retinal,Hereditary Retinoblastomas,Neuroblastomas, Retinal,Retinal Glioblastoma,Retinal Glioblastomas,Retinal Glioma,Retinal Gliomas,Retinal Neuroblastoma,Retinal Neuroblastomas,Retinoblastoma Eye Cancer,Retinoblastoma Eye Cancers,Retinoblastoma, Familial,Retinoblastoma, Hereditary,Retinoblastoma, Sporadic,Retinoblastomas,Retinoblastomas, Familial,Retinoblastomas, Hereditary,Retinoblastomas, Sporadic,Sporadic Retinoblastomas