-transparent.png){kind=logo}
The effects of equipotent glucose-lowering doses of insulinlike growth factor I (IGF-I) and insulin on tracer-determined glucose kinetics and several metabolites were compared in 14 experiments (7 in each group) in fasted, totally depancreatized dogs. This model prevented variations in insulin secretion induced by IGF-I and permitted evaluation of the effects of IGF-I on extrapancreatic glucagon. Steady-state moderate hyperglycemia (9.9 +/- 0.2 mM) was maintained by a subbasal intraportal infusion of insulin (1.29 +/- 0.17 pmol.kg-1.min-1). This was continued throughout the experiment, allowing evaluation of IGF-I effects on insulin clearance. Human recombinant IGF-I or insulin was given intravenously as a primed infusion for 90 min, followed by a 50-min recovery period. The dose of IGF-I was a 2.6-nmol/kg bolus plus 57.4 pmol.kg-1.min-1. The insulin dose required to induce the same plasma glucose decline as IGF-I (44 +/- 6 vs. 43 +/- 5%, NS) was 9-12 times lower (0.06-nmol/kg bolus + 6.4 +/- 0.6 pmol.kg-1.min-1). However, the mechanism of this decline differed with IGF-I and insulin; glucose production was much less suppressed (25 +/- 9 vs. 42 +/- 11%, P less than 0.001) and glucose utilization was more stimulated (68 +/- 18 vs. 38 +/- 19%, P less than 0.05) with IGF-I.(ABSTRACT TRUNCATED AT 250 WORDS)
A Giacca, and
R Gupta, and
S Efendic, and
K Hall, and
A Skottner, and
L Lickley, and
M Vranic
May 1994,
European journal of clinical investigation,
A Giacca, and
R Gupta, and
S Efendic, and
K Hall, and
A Skottner, and
L Lickley, and
M Vranic
October 1997,
Journal of applied physiology (Bethesda, Md. : 1985),
A Giacca, and
R Gupta, and
S Efendic, and
K Hall, and
A Skottner, and
L Lickley, and
M Vranic
January 2001,
The Journal of endocrinology,
A Giacca, and
R Gupta, and
S Efendic, and
K Hall, and
A Skottner, and
L Lickley, and
M Vranic
January 1966,
Nihon geka hokan. Archiv fur japanische Chirurgie,
A Giacca, and
R Gupta, and
S Efendic, and
K Hall, and
A Skottner, and
L Lickley, and
M Vranic
May 1992,
The American journal of physiology,
A Giacca, and
R Gupta, and
S Efendic, and
K Hall, and
A Skottner, and
L Lickley, and
M Vranic
January 1973,
Surgical forum,
A Giacca, and
R Gupta, and
S Efendic, and
K Hall, and
A Skottner, and
L Lickley, and
M Vranic
January 1976,
Journal of surgical oncology,
A Giacca, and
R Gupta, and
S Efendic, and
K Hall, and
A Skottner, and
L Lickley, and
M Vranic
January 1940,
The Journal of physiology,
A Giacca, and
R Gupta, and
S Efendic, and
K Hall, and
A Skottner, and
L Lickley, and
M Vranic
June 2011,
Molecular and cellular endocrinology,
A Giacca, and
R Gupta, and
S Efendic, and
K Hall, and
A Skottner, and
L Lickley, and
M Vranic
September 1999,
Endocrinology,
