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Synthesis and biological evaluation of acyclic phosphonic acid nucleoside derivatives. 2013
Philip Wainwright, and
Adrian Maddaford, and
Xiurong Zhang, and
Helen Billington, and
David Leese, and
Rebecca Glen, and
David C Pryde, and
Donald S Middleton, and
Peter T Stephenson, and
Scott Sutton
a Peakdale Molecular Ltd. , Chapel-en-le-Frith , Derbyshire , United Kingdom.
As part of a project to generate a library of nucleosides as potential antiviral agents, a small subset of novel acyclic phosphonic acid nucleosides was prepared. Practical synthetic routes are described for three targets, which were then tested against HIV, hepatitis C virus (HCV), and Dengue virus.
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