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We evaluated the safety and efficacy of intravenous mexiletine and a method for converting from intravenous to oral mexiletine therapy. Fifteen patients with repetitive ventricular ectopy (13 had ventricular tachycardia) received intravenous mexiletine at a rate of 10 mg/min for 30 to 60 minutes. Ventricular ectopy was suppressed with minimal side effects in 10 of 15 subjects. Oral mexiletine was begun immediately after completion of the intravenous infusion at a dose of 10 mg/kg/24 hr in the 10 responders to intravenous therapy. In eight, the oral dose was effective in suppressing the arrhythmia, but it induced side effects in three of them. In one of these three, dose reduction resulted in adequate arrhythmia control with acceptable toxicity. In the two who did not respond to the original dose, a larger dose (15 mg/kg/24 hr) induced arrhythmia control with acceptable side effects in one subject. Thus rapid control of nonsustained repetitive ventricular arrhythmia can be achieved with intravenous mexiletine in about two thirds of patients, and conversion to oral therapy can often be achieved smoothly without significant arrhythmia recurrence.
L N Horowitz, and
A M Greenspan, and
S R Spielman, and
S J Frye, and
L A Yacone, and
D T Lowenthal
April 1983,
American heart journal,
L N Horowitz, and
A M Greenspan, and
S R Spielman, and
S J Frye, and
L A Yacone, and
D T Lowenthal
May 1984,
American heart journal,
L N Horowitz, and
A M Greenspan, and
S R Spielman, and
S J Frye, and
L A Yacone, and
D T Lowenthal
January 1978,
Annales de cardiologie et d'angeiologie,
L N Horowitz, and
A M Greenspan, and
S R Spielman, and
S J Frye, and
L A Yacone, and
D T Lowenthal
June 1984,
La Clinica terapeutica,
L N Horowitz, and
A M Greenspan, and
S R Spielman, and
S J Frye, and
L A Yacone, and
D T Lowenthal
January 2022,
Clinical and experimental nephrology,
L N Horowitz, and
A M Greenspan, and
S R Spielman, and
S J Frye, and
L A Yacone, and
D T Lowenthal
October 1964,
Circulation,
L N Horowitz, and
A M Greenspan, and
S R Spielman, and
S J Frye, and
L A Yacone, and
D T Lowenthal
January 1984,
European journal of clinical pharmacology,
L N Horowitz, and
A M Greenspan, and
S R Spielman, and
S J Frye, and
L A Yacone, and
D T Lowenthal
January 1987,
Fundamental & clinical pharmacology,
L N Horowitz, and
A M Greenspan, and
S R Spielman, and
S J Frye, and
L A Yacone, and
D T Lowenthal
January 1982,
La Clinica terapeutica,
L N Horowitz, and
A M Greenspan, and
S R Spielman, and
S J Frye, and
L A Yacone, and
D T Lowenthal
October 1983,
Annales de cardiologie et d'angeiologie,
