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In an attempt to induce circulating interferon (IFN) chronically, C57BL/6 or Balb/cBy mice received daily injections or continuous infusion of polyriboinosinic:polyribocytidilic acid [poly(I:C)] i.p. for 7 days. Significantly higher plasma IFN was present in C57BL/6 mice receiving poly(I:C) via continuous infusion compared with daily injections. Spleen and bone marrow natural killer (NK) cells were elevated only in the group receiving poly(I:C) continuously. Little IFN was induced acutely in Balb/cBy mice and none was present after chronic infusion of poly(I:C). NK cells were not elevated. Continuous infusion of poly(I:C) appears to overcome the hyporesponsiveness to repeated IFN induction in a susceptible mouse strain.
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