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The human pro alpha 2(I) collagen gene was analysed for the presence of restriction fragment length polymorphisms. DNA from randomly selected unrelated persons of three Southern African populations was cleaved with one of eight different restriction enzymes, electrophoresed, blotted, and hybridised with cDNA and genomic probes specific for the pro alpha 2(I) gene. An MspI polymorphism was detected which results from the loss of a cleavage site within the 3' half of the gene. In two of the populations studied, the polymorphism occurred at significant frequencies, and should therefore prove useful as a genetic marker for the study of inherited disorders of connective tissue involving collagen structure or biosynthesis.
A F Grobler-Rabie, and
D K Brebner, and
S Vandenplas, and
G Wallis, and
R Dalgleish, and
R E Kaufman, and
A J Bester, and
C G Mathew, and
C D Boyd
November 1987,
The Journal of biological chemistry,
A F Grobler-Rabie, and
D K Brebner, and
S Vandenplas, and
G Wallis, and
R Dalgleish, and
R E Kaufman, and
A J Bester, and
C G Mathew, and
C D Boyd
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A F Grobler-Rabie, and
D K Brebner, and
S Vandenplas, and
G Wallis, and
R Dalgleish, and
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C D Boyd
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D K Brebner, and
S Vandenplas, and
G Wallis, and
R Dalgleish, and
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C D Boyd
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D K Brebner, and
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R Dalgleish, and
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A J Bester, and
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The Journal of biological chemistry,
A F Grobler-Rabie, and
D K Brebner, and
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A J Bester, and
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C D Boyd
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Nucleic acids research,
A F Grobler-Rabie, and
D K Brebner, and
S Vandenplas, and
G Wallis, and
R Dalgleish, and
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A J Bester, and
C G Mathew, and
C D Boyd
May 1986,
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Nucleic acids research,
A F Grobler-Rabie, and
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Nucleic acids research,
A F Grobler-Rabie, and
D K Brebner, and
S Vandenplas, and
G Wallis, and
R Dalgleish, and
R E Kaufman, and
A J Bester, and
C G Mathew, and
C D Boyd
August 1984,
Nucleic acids research,
